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ProteomicsDecreased CSTB, RAGE and Axl receptor is associated with Zika infection in the human placenta
Zika virus (ZIKV) compromises the placental integrity infecting the fetus. However, the mechanisms associated with ZIKV penetration into the placenta leading to fetal infection, are unknown. Cystatin B (CSTB), the receptor for advanced glycation end products (RAGE), and tyrosine-protein kinase recep...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037388 | Pride
Hofbauer cells Trophoblasts Rage Human placenta Axl Cstb Zika virus Quantitative proteomics tmt 
TranscriptomicsGene expression data of cultured primary microglia from neonatal control and Cstb-/- mice.
Cystain B (Cstb) is a ubiquitously expressed cysteine protease inhibitor and mutations of the CSTB gene lead to the neurodegenerative disease progressive myoclonus epilepsy of Unverricht-Lundorg type (EPM1). We are interested in the microglia-specific, Cstb-dependent gene-expression changes in mice ...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-64823 | biostudies-arrayexpress
ProteomicsCSTB increases autophagic flux by sustaining the proteolytic activity of Cathepsin B and fuels glycolysis in pancreatic cancer
Cathepsins interact with CSTB were analysed by LC/MS
ORGANISM(S): Homo Sapiens 
2022-11-05 | PXD037970 |
TranscriptomicsTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
RNA-seq analysis on neurospheres derived from wt and Cstb-knockout mouse embryo brains before differentiation and during differentiation at days 1, 5, and 12.
ORGANISM(S): Mus musculus 
2021-12-31 | E-MTAB-8934 | biostudies-arrayexpress
TranscriptomicsGene expression alterations in the cerebellum and granule neurons of Cstb-/- mouse are associated with early synaptic changes and inflammation
Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an inherited neurodegenerative disease with myoclonus, seizures and ataxia, caused by the mutations in cystatin B (CSTB) gene. In an approach towards understanding the molecular basis of pathogenic events in EPM1 we have utilized t...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-47516 | biostudies-arrayexpress
TranscriptomicsGene expression data of cultured primary microglia from neonatal control and Cstb-/- mice.
Cystain B (Cstb) is a ubiquitously expressed cysteine protease inhibitor and mutations of the CSTB gene lead to the neurodegenerative disease progressive myoclonus epilepsy of Unverricht-Lundorg type (EPM1). We are interested in the microglia-specific, Cstb-dependent gene-expression changes in mice ...
ORGANISM(S): Mus musculus 
2016-06-29 | GSE64823 | GEO
GenomicsTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Transcriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
PRJEB37759 | ENA
UnknownGene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia.
Not available
S-EPMC4927094 | biostudies-literature
TranscriptomicsGene expression alterations in the cerebellum and granule neurons of Cstb-/- mouse are associated with early synaptic changes and inflammation
Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an inherited neurodegenerative disease with myoclonus, seizures and ataxia, caused by the mutations in cystatin B (CSTB) gene. In an approach towards understanding the molecular basis of pathogenic events in EPM1 we have utilized t...
ORGANISM(S): Mus musculus 
2014-03-03 | GSE47516 | GEO
UnknownStaphylococcus aureus CstB Is a Novel Multidomain Persulfide Dioxygenase-Sulfurtransferase Involved in Hydrogen Sulfide Detoxification.
Not available
S-EPMC4874178 | biostudies-literature
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