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GenomicsIllumina Sequencing data of the influence of Insulator Proteins on chromatin
The Drosophila insulator-binding proteins (IBPs) dCTCF/Beaf32 mark the physical borders of chromosomal domains involving co-factors that participate in long-range interactions. Chromosomal borders are further enriched in specific histone modifications yet the implication of histone modifiers and nuc...
ORGANISM(S): Drosophila melanogaster 
2014-04-30 | E-GEOD-57166 | biostudies-arrayexpress
GenomicsChromatin Poises miRNA- and Protein-coding Genes for Expression
Chromatin modifications have been implicated in regulation of gene expression. While association of certain modifications with expressed or silent genes has been established, it remains unclear how changes in chromatin environment relate to changes in gene expression. In this report, we used ChIP-Se...
ORGANISM(S): Homo sapiens 
2009-08-10 | E-GEOD-16657 | biostudies-arrayexpress
TranscriptomicsEpigenetic Repogramming by an Environmental Carcinogen Through Chromatin Domain Disruption [RNA-Seq]
Alterations in chromatin modifications, including DNA methylation and histone modification patterns, have been characterized under exposure of several environmental pollutants, including nickel. As with other carcinogenic metals, the mutagenic potential of nickel compounds is low and is not well cor...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-56052 | biostudies-arrayexpress
GenomicsEpigenetic Repogramming by an Environmental Carcinogen Through Chromatin Domain Disruption [ChIP-Seq]
Alterations in chromatin modifications, including DNA methylation and histone modification patterns, have been characterized under exposure of several environmental pollutants, including nickel. As with other carcinogenic metals, the mutagenic potential of nickel compounds is low and is not well cor...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-56051 | biostudies-arrayexpress
GenomicsPol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes (I)
Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of many examples, the transcription of non-coding RNA genes by RNA polymerase (pol) III is less well characterized. Here we profile the epigenetic features of pol III target genes throughout the human gen...
ORGANISM(S): Homo sapiens 
2010-04-25 | E-GEOD-20040 | biostudies-arrayexpress
GenomicsCTCF demarcates chromatin domains
Insulators are DNA elements, which prevent inappropriate interactions between the neighboring regions of the genome. They can be functionally classified as either enhancer blockers or domain barriers. CTCF (CCCTC binding factor) is the only known major insulator binding protein in the vertebrates a...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-12889 | biostudies-arrayexpress
TranscriptomicsPol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes (II)
Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of many examples, the transcription of non-coding RNA genes by RNA polymerase (pol) III is less well characterized. Here we profile the epigenetic features of pol III target genes throughout the human gen...
ORGANISM(S): Homo sapiens 
2010-04-25 | E-GEOD-20071 | biostudies-arrayexpress
GenomicsGenomic Profiling of HMGN1 Reveals an Association with Chromatin at Regulatory Regions
High mobility group (HMG) proteins interact with other architectural proteins to regulate chromatin structure. We performed genome-wide mapping experiments to examine the distribution of HMGN1 across the human genome. We discovered that HMGN1 proteins are enriched at regulatory regions such as DNas...
ORGANISM(S): Homo sapiens 
2010-11-30 | E-GEOD-25674 | biostudies-arrayexpress
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