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The enduring effects of early-life HFHS exposure and microbiota-targeted interventions on blood metabolome in adult female and male mice

Blood metabolomics of 12-week-old female and male C57BL/6J mice that were exposed to either a control or an unhealthy high-fat/high-sugar (HFHS) diet during early-life, or early-life HFHS diet supplemented with a microbiota-targeted intervention (either a prebiotic combination (fructo-oligosaccha...

2026-01-27 | MTBLS12714 | MetaboLights

RAS-p110α signalling pathway in macrophages and its impact on both the initiation and resolution of inflammation

This study presents a secretome analysis of bone marrow-derived macrophages (BMDMs) from wild-type (WT) and RAS-p110α-disrupted macrophages. Samples were collected under both unstimulated conditions and during phagocytosis of apoptotic cells. The aim was to identify differential regulatory factors s...

ORGANISM(S): Mus musculus (Mouse)

2025-04-28 | PXD057794 | Pride