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ProteomicsEvolutionary Instability of CUG-Leu in the Genetic Code of Budding Yeasts
The standard genetic code is almost universal, and the evolutionary factors that caused a few organisms to deviate from it are poorly understood. We report that three independent changes of the genetic code occurred during the evolution of budding yeasts, each of which was a reassignment of the codo...
ORGANISM(S): Komagataella phaffii Babjeviella inositovora [Candida] boidinii Lipomyces starkeyi Kuraishia capsulata Nakazawaea wickerhamii Peterozyma xylosa Ascoidea rubescens Citeromyces matritensis Pachysolen tannophilus Saturnispora dispora Tortispora caseinolytica Ambrosiozyma philentoma Candida parapsilosis Pichia kudriavzevii Cyberlindnera jadinii Ogataea polymorpha Saccharomycopsis capsularis 
2018-05-21 | PXD008827 | Pride
Genetic code yeast cug 
UnknownUnveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.
Not available
S-EPMC3161578 | biostudies-literature
UnknownThe Fungus Candida albicans Tolerates Ambiguity at Multiple Codons.
Not available
S-EPMC4814463 | biostudies-literature
GenomicsMistranslation accelerates the adaptation of Candida albicans to Fluconazole
The leucine CUG codon was reassigned to serine in the fungal pathogen Candida albicans. To clarify the biological role of this tuneable codon ambiguity on drug resistance, we evolved C. albicans strains that were engineered to mistranslate the CUG codon at constitutively elevated levels, in the pres...
ORGANISM(S): Candida albicans 
2016-10-27 | E-SYBR-13 | biostudies-arrayexpress
ProteomicsAnalysis of protein biosynthesis errors in Candida albicans.
Recent works show that protein mistranslation is widespread in nature and that both single cell or multicellular organisms can take advantage of it, by regulating its levels, under specific physiological and environmental conditions. In C. albicans, it leads to increased morphological and physiologi...
ORGANISM(S): Candida albicans (Yeast) 
2024-09-09 | PXD047025 | Pride
Candida albicans Proteogenomics Cug ambiguity Mistranslation 
UnknownAlternative CUG Codon Usage in the Halotolerant Yeast Debaryomyces hansenii: Gene Expression Profiles Provide New Insights into Ambiguous Translation.
Not available
S-EPMC9502446 | biostudies-literature
TranscriptomicsMistranslation accelerates the evolution of antifungal drug resistance in Candida albicans [Gene expression]
The fungal pathogen Candida albicans and other pathogens of the CTG clade reassigned the leucine CUG codon to serine and tolerate highly variable levels of both serine and leucine at CUG positions in response to environmental cues. Previous studies found that increased leucine misincorporation level...
ORGANISM(S): Candida albicans 
2017-07-18 | GSE60121 | GEO
GenomicsMistranslation accelerates the evolution of antifungal drug resistance in Candida albicans [CGH]
The fungal pathogen Candida albicans and other pathogens of the CTG clade reassigned the leucine CUG codon to serine and tolerate highly variable levels of both serine and leucine at CUG positions in response to environmental cues. Previous studies found that increased leucine misincorporation level...
ORGANISM(S): Candida albicans SC5314 Candida albicans 
2017-07-18 | GSE60120 | GEO
UnknownAminoacylation and translational quality control strategy employed by leucyl-tRNA synthetase from a human pathogen with genetic code ambiguity.
Not available
S-EPMC3834818 | biostudies-literature
UnknownA genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans.
Not available
S-EPMC2246281 | biostudies-literature
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