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Investigation of whole genome gene expression level changes in Plasmodium falciparum 3D7 delta-PfPuf2 mutant, compared to the wild-type strain 3D7. The mutation engineered into this strain render tanslational control. The mutants analyzed in this study are further described in Miao J, Li J, Fan Q, ...
ORGANISM(S): Plasmodium falciparum 3D7 
Expression analysis of Plasmodium falciparum 3D7 delta-PfPuf2 mutant
Recent studies of the Puf family of RNA-binding proteins revealed that besides their traditional roles in translational regulation of mRNAs, some Puf proteins are also involved in ribosome biogenesis by binding rRNA. In this study, we report the role of a Puf-like protein (Puf3) in ribosome biogenes...
ORGANISM(S): Plasmodium falciparum UGK 730.2 
2018-03-12 | PXD007978 | Pride
Gametocytes are obligate for the transmission of malaria parasite to mosquito. This study reports the first comprehensive proteomes of accurately separated mature male and female Plasmodium falciparum gametocytes using a transgenic line. the proteomes revealed significant differences that are consis...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2017-01-30 | PXD003556 | Pride
Here, we characterized an RNA binding protein (RBP), PfDOZI, which is an integral cytoplasmic component of RNP granule. We observed that deleting pfdozi led to an asexual growth advantage due to the escalated merozoite invasion capacity. Also, pfdozi disruption resulted in a significant impairment i...
ORGANISM(S): Plasmodium falciparum 
2024-04-16 | PXD020862 | Pride
In malaria parasites, the regulation of mRNA translation, storage and degradation during development and life stage transitions remains largely unknown. Here, we functionally characterized the DEAD-box RNA helicase PfDOZI in P. falciparum. Disruption of pfdozi enhanced asexual proliferation but redu...
ORGANISM(S): Plasmodium falciparum MLW.2749 
2024-04-30 | PXD051782 | Pride
Transcriptome of ring-stage parasites responses to stress conditions upon knockdown of PfGCN5
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