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GenomicsChromatin Signatures in Multipotent Human HSCs Indicate the Fate of Bivalent Genes during Differentiation
Histone modifications have been implicated in stem cell maintenance and differentiation. We have analyzed genome-wide changes in gene expression and histone modifications during differentiation of multipotent human primary hematopoietic stem cells/progenitor cells (HSCs/HPCs) into erythrocyte precur...
ORGANISM(S): Homo sapiens 
2009-01-09 | E-GEOD-12646 | biostudies-arrayexpress
UnknownCuI-catalyzed synthesis of multisubstituted pyrido[1,2-a]pyrimidin-4-ones through tandem Ullmann-type C-N cross-coupling and intramolecular amidation reaction.
Not available
S-EPMC10424054 | biostudies-literature
ProteomicsProteomic and metabolic profile analysis of low-temperature storage responses in Ipomoea batata Lam. tuberous roots
Our proteomic and metabolic profile analysis of sweetpotato roots stored at low temperature reveal that the antioxidant enzymes activities, proline and especially soluble sugar content were significantly increased. Most of the DEPs were implicated in phenylpropanoids and followed by starch and sucro...
ORGANISM(S): Ipomoea batatas 
2021-09-09 | PXD017728 | Pride
Proteometabolomic Chilling tolerance Low-temperature storage Sweetpotato Starch metabolism 
TranscriptomicsSAD1 dynamically regulates alternative splicing and stress tolerance
Although Sm-like proteins (LSMs) form the core of U6 RNPs and function in pre-mRNA splicing, little is known regarding their regulatory role in selection of splice sites, alternative splicing (AS) and splicing efficiency in eukaryotes. The Arabidopsis SAD1 locus encodes the LSM5 protein and was defi...
ORGANISM(S): Arabidopsis thaliana 
2013-11-01 | E-MTAB-4336 | biostudies-arrayexpress
Transcriptomicsrat small intestine samples
Experiment description 1. Experimental design 1) Authors, laboratory, and contact: Xue-Lin Cui1, Patricia Soteropoulos2, Peter Tolias2, Ronaldo P. Ferraris1: 1Dept. of Pharmacology and Physiology, UMDNJ-New Jersey Medical School, Newark, NJ 07103-2714, 2Center for Applied Genomics, PHRI, 225 Warre...
ORGANISM(S): Rattus norvegicus 
2010-06-09 | E-GEOD-996 | biostudies-arrayexpress
UnknownSIRT1 in B[a]P-induced lung tumorigenesis.
Not available
S-EPMC4694977 | biostudies-literature
GenomicsGenome-wide mapping of HATs and HDACs in human CD4+ T cells
Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to control histone acetylation. As acetylation is a histone mark for active transcription, HATs have been associated with active and HDACs with inactive genes. We describe here genome-wide mapping of HATs and HDACs ...
ORGANISM(S): Homo sapiens 
2009-08-20 | E-GEOD-15735 | biostudies-arrayexpress
TranscriptomicsStereo-sequencing: 3D Transcriptome of the mouse embryo at gastrulation
To glean an appreciation of the holistic genetic activity in the gastrulating mouse embryo, we performed a genome-wide spatial transcriptome analysis (Stereo-seq), using a low-cell number sequencing protocol on laser microdissected samples of epiblast cells with retained positional address. The 3D t...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-65924 | biostudies-arrayexpress
MetabolomicsTranscriptomics and metabolomics analysis reveal the anti-oxidation and immune boosting effects of mulberry leaves in growing mutton sheep

INTRODUCTION: Currently, the anti-oxidation of active ingredients in mulberry leaves (MLs) and their forage utilization is receiving increasing attention. Here, we propose that MLs supplementation improves oxidative resistance and immunity.

METHODS: We con...

2023-02-23 | MTBLS6516 | MetaboLights
ProteomicsDe-2-hydroxyisobutyrylation of clusterin attenuates neuropathology and memory deficits in an Alzheimer's disease mouse model
Backgroud Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder for which there is currently no cure, representing a serious clinical challenge. Lysine 2-hydroxyisobutyrylation (Khib) is a newly discovered post-translational modification that has been found to be wid...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-04 | PXD066261 | Pride
Clusterin Adeno-associated viruse 2-hydroxyisobutyrylation Post-translational modification Alzheimer's disease 
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