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ProteomicsGlobal lysine acetylation and 2-hydroxyisobutyrylation reveal the metabolism conversion mechanism in Giardia lamblia
Giardia lamblia (G. lamblia) disease is a zoonosis with a-infection rate affecting the general population of the world. Despite the constant possibility of damage due to their own metabolism, G. lamblia have survived and evolved to adapt to various environments. However, research on energy-metabolis...
ORGANISM(S): Giardia lamblia P15 
2021-01-04 | PXD022317 | Pride
Giardia lamblia  acetylation  2-hydroxyisobutyrylation  metabolism conversion. 
ProteomicsQuantitative Proteomics Reveals the role of Lysine 2-hydroxyisobutyrylation Pathway mediated by Tip60
Lysine 2-hydroxyisobutyrylation (Khib) is an evolutionary conserved and widespread protein posttranslational modification (PTM) that has diverse cellular functions. Recently, it has been demonstrated that Khib can be regulated by p300 and Tip60. Although the specific Khib substrates mediated by p300...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD029297 | Pride
Lysine 2-hydroxyisobutyrylation Tip60 Posttranslational modification Substrate Quantitative proteomics 
ProteomicsGlobal PTM Mapping for Lysine 2-hydroxyisobutyrylation in one Oryza Sativa Japonica sample
By the combination of affinity enrichment and high-resolution LC-MS/MS analysis, large-scale lysine 2-hydroxyisobutyrlome analysis was performed in Oryza Sativa. Altogether, 9916 lysine 2-hydroxyisobutyrylation sites in 2512 protein groups were identified. Intensive bioinformatic analysis was then c...
ORGANISM(S): Oryza sativa (Rice) 
2018-10-26 | PXD005986 | Pride
Lysine 2-hydroxyisobutyrylation oryza sativa post-translational modification 
ProteomicsLysine 2-hydroxyisobutyrylation contributes to aflatoxin production in Aspergillus flavus
Aspergillus flavus contaminates crops during preharvest and post-harvest periods and produce carcinogenic mycotoxin aflatoxins posing severe threat to food safety and human health. Lysine 2-hydroxyisobutyrylation is one of the most important reversible post-translational modifications and plays a vi...
ORGANISM(S): Aspergillus flavus partitivirus 1 
2022-06-06 | PXD030912 | Pride
Aspergillus flavus  lysine 2-hydroxyisobutyrylation  aflatoxin Secondary metabolism 
ProteomicsHuman atrial tissue modification of Lysine 2-hydroxyisobutyrylation
The role of modification of histone lysine 2-hydroxyisobutyrylation in atrial fibrillation is unclear and we hence explored the role of 2-hydroxyisobutyrylation in atrial fibrillation. Tandem Mass Tag proteomics method and other verification technologies in tissues and cells identified the protein p...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD032154 | Pride
Post-translational modification Human 2-hydroxyisobutyrylation 
ProteomicsTandem mass tags (TMT)–based quantitative proteomics approach quantified in 2-hydroxyisobutyrylation site of rice spikelets and Ustilaginoidea virens by mass spectrometry.
Rice false smut, caused by the pathogenic ascomycete fungus Ustilaginoidea virens (teleomorph: Villosiclava virens), is one of the most devastating grain diseases in the majority of rice-growing areas of the world. Lysine 2-hydroxyisobutyrylation (Khib) is a novel post-translational modification (PT...
ORGANISM(S): Ustilaginoidea virens Oryza sativa (Rice) 
2023-06-06 | PXD019114 | Pride
2-hydroxyisobutyrylation  tmt  mass spectrometry 
ProteomicsIdentification and analysis of histone lysine 2-hydroxyisobutyrylation in Arabidopsis
Lysine 2-hydroxyisobutyrylation (Khib) is a novel type of histone acylation in eukaryotes, but its prevalence and genomic function in higher plants remain unclear. Using mass spectrometry, we identified histone lysine 2-hydroxyisobutyrylation in Arabidopsis
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-06-09 | PXD018017 | Pride
Lysine 2-hydroxyisobutyrylation  chromartin  histone acylation  arabidopsis 
ProteomicsGlobal analysis of lysine 2-hydroxyisobutyrylation in wheat leaf
Lysine 2-hydroxyisobutyrylation (Khib) is a novel naturally occurring PTM, which is firstly discovered in histone. The system Khib detection at proteomics level has been performed in various species and tissues for the function and role characterization of Khib in biological activities. However, the...
ORGANISM(S): Triticum aestivum (Wheat) 
2021-06-10 | PXD020790 | Pride
2-hydroxyisobutyrylation Wheat 
ProteomicsLandscape of the Regulatory Elements for Lysine 2-Hydroxyisobutyrylation Pathway
This project reported a comprehensive global lysine 2-hydroxyisobutyrylome that provided a dataset of 6548 reliable lysine 2-hydroxyisobutyrylation (Khib) sites on 1725 proteins in HeLa cells. This dataset represents the first Khib proteome in mammalian cell to date, and illustrates a broad landscap...
ORGANISM(S): Homo sapiens (Human) 
2017-12-06 | PXD005414 | Pride
Hela Ptm Lysine 2-hydroxyisobutyrylation 
ProteomicsProteome-wide analysis of Lysine 2-Hydroxyisobutyrylation in Aspergillus fumigatus
Aspergillus fumigatus is the main culprit of invasive aspergillosis, which has a high mortality rate in immunocompromised patients. Lysine 2-hydroxyisobutyrylation is a highly conserved posttranslational modification found in a wide variety of organisms. In this study, we survey the biological impac...
ORGANISM(S): Aspergillus fumigatus Af293 
2024-01-26 | PXD041490 | Pride
Lysine 2-hydroxyisobutyrylation Aspergillus fumigatus Posttranslational modification Proteome 
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