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GenomicsCritical role of histone demethylase Jmjd3 in the regulation of CD4+ T cell differentiation
Epigenetic factors have been implicated in the regulation of CD4(+) T-cell differentiation. Jmjd3 plays a role in many biological processes, but its in vivo function in T-cell differentiation remains unknown. Here we report that Jmjd3 ablation promotes CD4(+) T-cell differentiation into Th2 and Th17...
ORGANISM(S): Mus musculus 
2015-06-13 | E-GEOD-58775 | biostudies-arrayexpress
GenomicsGlobal Mapping of Histone H3 K4 and K27 Trimethylation: Lineage Fate Determination of Differentiating CD4+ T Cells
Multipotential naïve CD4+ T cells differentiate into distinct lineages including Th1, Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4+ T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications ...
ORGANISM(S): Mus musculus 
2009-01-21 | E-GEOD-14254 | biostudies-arrayexpress
ProteomicsProteome profile of Traf6-OE OT-I T cells
Proteome profile of Traf6-OE OT-I T cells and EV OT-I cells after viral transfection
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD039327 | Pride
Mouse Lc-ms Traf6-oe ot-i t cells 
GenomicsGenome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types
We report genome-wide characterization of GATA3 binding sites in eleven well-defined developmental and effector cell types of the T lymphocyte lineage. By utilizing a conditional allele of GATA3, we investigated the impact of GATA3 expression on the mRNA expression patterns in several of these cell...
ORGANISM(S): Mus musculus 
2011-08-26 | E-GEOD-20898 | biostudies-arrayexpress
TranscriptomicsGenes regulated by T cell and B cell derived TNF in naive lymph nodes
We present a RNA microarray analysis of RNA`s extracted from naive mesenterial lymph nodes of mice with specific inactivation of tumor necrosis factor only in B cells (B-TNf mice) or in T- and B-cells (TB-TNF mice). Several genes are cooperatively regulated by T cell derived and B cell derived TNF ...
ORGANISM(S): Mus musculus 
2010-12-07 | E-GEOD-8610 | biostudies-arrayexpress
TranscriptomicsHistone methylations and gene expression in naïve, central (TCM) and effector (TEM) memory CD8 T cells.
Histone methylations play a major role in regulating the chromatin state and gene expression, yet little is known about their involvement in differential gene expression and function of memory CD8 T cells. Here, we report a genome-wide analysis of two histone H3 methylations (H3K4me3 and H3K27me3) ...
ORGANISM(S): Homo sapiens 
2009-03-06 | E-GEOD-14422 | biostudies-arrayexpress
ProteomicsTargeting Pim2 Improves Effector Function and Longevity of CD8 T cells in Cancer Immunotherapy
The Pim kinase family is critically involved in tumorigenesis, yet its function in primary T cells remains poorly understood. We previously reported that Pim2 negatively regulates T-cell responses to alloantigen. To investigate how Pim2 impacts anti-tumor immunity of CD8 T cells, we generated Pim2-/...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-08 | PXD059837 | Pride
Pim2 T cells Cancer Immunotherapy 
TranscriptomicsTLR4 ligands LPS and MPLA differentially regualte effector and memory CD8 T cell differentiation
Here we implemented a simple dendritic cell (DC)-mediated immunization approach to study the effects of commonly used adjuvants, Toll like receptor (TLR) ligands, on effector CD8 T cell differentiation and memory T cell development. To our surprise, we found that the TLR4 ligand LPS was far more sup...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-50764 | biostudies-arrayexpress
TranscriptomicsmiRNAs expression in the splenic CD4+ T cells and B cells isolated from MRL/lpr mice at 5 and 16 weeks of age
To identify any differentially expressed miRNAs in the CD4+ T cells of lupus. MicroRNAs (miRNAs) have been implicated as fine-tuning regulators controlling diverse biological processes at the level of posttranscriptional repression. Dysregulation of miRNAs has been described in various disease stat...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-21220 | biostudies-arrayexpress
GenomicsGenome-wide Analysis of Histone Methylations in Memory CD8+ T Cells
Histone methylations play a major role in regulating the chromatin state and gene expression, yet little is known about their involvement in differential gene expression and function of memory CD8 T cells. Here, we report a genome-wide analysis of two histone H3 methylations (H3K4me3 and H3K27me3) ...
ORGANISM(S): Homo sapiens 
2009-06-12 | E-GEOD-12616 | biostudies-arrayexpress
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