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ProteomicsTargeting Pim2 Improves Effector Function and Longevity of CD8 T cells in Cancer Immunotherapy
The Pim kinase family is critically involved in tumorigenesis, yet its function in primary T cells remains poorly understood. We previously reported that Pim2 negatively regulates T-cell responses to alloantigen. To investigate how Pim2 impacts anti-tumor immunity of CD8 T cells, we generated Pim2-/...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-08 | PXD059837 | Pride
Pim2 T cells Cancer Immunotherapy 
TranscriptomicsGene-expression profile in a series of non-Hodgkin lymphoma (NHL) patients
PIM serine/threonine kinases are overexpressed, translocated or amplified in multiple B-cell lymphoma types. We have explored the frequency and relevance of PIM expression in different B-cell lymphoma types, and investigated whether PIM inhibition could be a rational therapeutic approach. Increased ...
ORGANISM(S): Homo sapiens 
2011-10-16 | E-GEOD-32018 | biostudies-arrayexpress
ProteomicsProteomics of 24 h TCR activated wild-type and Pim1/Pim2 double knockout CD4 and CD8 T cells
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051198 | Pride
Lc-msms Mouse Pim1 Pim2 T lymphocyte Pim kinase 
UnknownPIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis.
Not available
S-EPMC5928357 | biostudies-literature
ProteomicsProteomics of Day 6 IL-2 or IL-15 expanded wild-type and Pim1/Pim2 double knockout CD8+ T cells.
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051213 | Pride
Lc-msms Mouse Pim1 Pim2 Cytotoxic t lymphocyte Pim kinase Il-2 Il-15 
UnknownCHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis.
Not available
S-EPMC3937083 | biostudies-literature
TranscriptomicsUncovering the Role of PIM2 in Modulating MCL1 Dependency and Activation of ISR-Mediated NOXA Expression
Our study delves into the intricate dynamics of the integrated stress response (ISR) axis, focusing on the pivotal role of PIM2 kinase and its interaction with the BCL2 family of proteins, revealing crucial mechanisms governing cell survival and tumor progression. Elevated PIM2 expression is a hallm...
ORGANISM(S): Homo sapiens 
2024-11-29 | GSE266112 | GEO
UnknownTargeting PIM2 by JP11646 results in significant antitumor effects in solid tumors.
Not available
S-EPMC9387562 | biostudies-literature
UnknownEngineered Fully Human Single-Chain Monoclonal Antibodies to PIM2 Kinase.
Not available
S-EPMC8588357 | biostudies-literature
UnknownRegulation of cagA-Helicobacter on gastric PIM2 expression in gastric cancer.
Not available
S-EPMC11491992 | biostudies-literature
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