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ProteomicsDissection of IL-2 and IL-15 signaling pathways
The aim of this study was to compare the signaling cascades initiated by the two closely related cytokines IL-2 and IL-15. Considering the relevance of protein tyrosine phosphorylation in signal transduction, in order to quantify changes in protein phosphorylation in response to IL-2 and IL-15, we c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080767 | MassIVE
ProteomicsCharacterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes
Despite extensive investigation, it remains a paradox that IL-2 and IL-15 can differentially modulate the immune response using the same signaling receptors. In our previous work, we dissected the phosphotyrosine-driven signaling cascades triggered by both cytokines in Kit225 T-cells unveiling subtl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080850 | MassIVE
ProteomicsDissection of IL-2 and IL-15 signaling pathways
The aim of this study was to compare the signaling cascades initiated by the two closely related cytokines IL-2 and IL-15. Considering the relevance of protein tyrosine phosphorylation in signal transduction, in order to quantify changes in protein phosphorylation in response to IL-2 and IL-15, we c...
ORGANISM(S): Homo sapiens (Human) 
2014-09-23 | PXD001129 | Pride
Silac Phosphotyrosine Signaling Il-2 Il-15 
TranscriptomicsEffect of anti-IL-15 administration on T cell and NK cell homeostasis in rhesus macaques (TEM)
Analysis of the effect of anti-IL-15 monoclonal antibody treatment on T cell and NK cell homeostasis in rhesus macaques. The hypothesis tested in the present study was that repeated administrations of a rhesusized anti-IL-15 monoclonal antibody would block IL-15 activity in vivo and result in change...
ORGANISM(S): Macaca mulatta 
2016-09-07 | E-GEOD-76796 | biostudies-arrayexpress
TranscriptomicsEffect of anti-IL-15 administration on T cell and NK cell homeostasis in rhesus macaques (TCM)
Analysis of the effect of anti-IL-15 monoclonal antibody treatment on T cell and NK cell homeostasis in rhesus macaques. The hypothesis tested in the present study was that repeated administrations of a rhesusized anti-IL-15 monoclonal antibody would block IL-15 activity in vivo and result in change...
ORGANISM(S): Macaca mulatta 
2016-09-07 | E-GEOD-76785 | biostudies-arrayexpress
TranscriptomicsMechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15
Interleukin-15 (IL-15) and IL-2 possess distinct immunological functions despite both signaling through IL-2Rβ and the common cytokine receptor γ-chain, γc, We find that in the IL-15/IL-15Rα/IL-2Rβ/γc quaternary complex structure, IL-15 heterodimerizes IL-2Rβ and γc identically to the IL-2/IL-2Rα/IL...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-40350 | biostudies-arrayexpress
ProteomicsCharacterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes
Despite extensive investigation, it remains a paradox that IL-2 and IL-15 can differentially modulate the immune response using the same signaling receptors. In our previous work, we dissected the phosphotyrosine-driven signaling cascades triggered by both cytokines in Kit225 T-cells unveiling subtl...
ORGANISM(S): Homo sapiens (Human) 
2016-08-08 | PXD002386 | Pride
Phosphorylation Il-2 Receptor complex assembly Il-15 Interactome 
TranscriptomicsMurine CD8+ Pmel Lymphocytes IL-2 vs. IL-15
Central memory tumor-reactive CD8+ T cells confer superior antitumor immunity compared to effector memory T cells
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2578 | biostudies-arrayexpress
ProteomicsQualitatively Different T Cell Phenotypic Responses to IL-2 versus IL-15 are Unified by Identical Dependences on Receptor Signal Strength and Duration
3 biological replicates of F15R-Kit cells stimulated with 500pM IL-2 or IL-15 for 15 minutes, and two biological replicates of unstimulated cells (total 8 conditions) were iTRAQ8plex labeled, combined and analyzed together. Phosphotyrosine peptides were enriched for by immunoprecipitation followed b...
ORGANISM(S): Homo sapiens (Human) 
2013-11-07 | PXD000440 | Pride
Phosphotyrosine Quantification Itraq8plex Il-2 Il-15 Phosphorylation 
TranscriptomicsRNA Expression Data from IL-15-/- and IL-15+/+ TAX-LUC Mouse Tumors
IL-15 is recognized as a promising candidate for tumor immunotherapy and has been described as both a promoter of cancer and a promoter of anti-cancer immunity. IL-15 was discovered in cells transformed by HTLV-1, the etiologic agent of adult T cell leukemia / lymphoma (ATL) and the human retrovirus...
ORGANISM(S): Mus musculus 
2013-06-11 | E-GEOD-46072 | biostudies-arrayexpress
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