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ProteomicsAcetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
The acetyl-CoA transporter, AT-1 (also referred to as SLC33A1), is a key member of the endoplasmic reticulum (ER) acetylation machinery; it transports acetyl-CoA from the cytosol into the ER lumen where it serves as donor of the acetyl group for Nε-lysine acetylation 1,2. Dysfunctional ER acetylatio...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-05 | PXD013736 | Pride
Mouse Suborganelle Liver Lc-ms/ms 
ProteomicsAcetyl-CoA flux maintains intracellular crosstalk and modulats engagement of the secretory pathway
Nε-lysine acetylation has emerged as a central mechanism to maintain quality control and protein homeostasis within the Endoplasmic Reticulum (ER) and secretory pathway. The ER acetylation machinery includes AT-1/SLC33A1, a membrane transporter that translocates acetyl-CoA from the cytosol to the ER...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD019770 | Pride
Mouse Brain Glycoproteomics Lc-ms/ms 
ProteomicsFinding the Sweet Spot in ERLIC Mobile Phase for Simultaneous Enrichment of N-Glyco and Phosphopeptides
Simultaneous enrichment of glyco- and phospho- peptides will benefit the studies of biological processes regulated by these post-translational modifications (PTMs). It will also reveal potential crosstalk between these two ubiquitous PTMs. Unlike custom designed multifunctional solid phase extractio...
ORGANISM(S): Homo sapiens (Human) 
2019-09-06 | PXD015179 | Pride
Mm.1s Glycosylation Erlic Phosphorylation Lc-ms/ms 
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