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ProteomicsDifferential expression of proteins in hematopoietic stem/progenitor cells lacking the Cullin-5 protein
Cullin proteins are scaffolds that coordinate assembly of cullin-RING E3 ubiquitin (Ub) ligases (CRL), complexes that control post-translational ubiquitin modification and degradation of cellular proteins. Cullin-5 (Cul5) coordinates assembly of CRL complexes containing the RING E3 ligase Rbx1/2, th...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-26 | PXD051430 | Pride
Cullin-5 Hematopietic stem and progenitor cells  lsk cells 
TranscriptomicsE2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...
ORGANISM(S): Mus musculus 
2009-03-23 | E-GEOD-14088 | biostudies-arrayexpress
GenomicsCullin-5 controls the number of megakaryocyte-committed stem cells to prevent excess megakaryopoiesis and thrombocytosis
Cullin-5 controls the number of megakaryocyte-committed stem cells to prevent excess megakaryopoiesis and thrombocytosis
PRJNA1114684 | ENA
UnknownCullin-5 deficiency orchestrates the tumor microenvironment to promote mammary tumor development through CREB1-CCL2 signaling.
Not available
S-EPMC9858512 | biostudies-literature
UnknownGold nanoparticles loaded with cullin-5 DNA increase sensitivity to 17-AAG in cullin-5 deficient breast cancer cells.
Not available
S-EPMC6584956 | biostudies-literature
UnknownRestriction of Src activity by Cullin-5.
Not available
S-EPMC2730496 | biostudies-literature
UnknownMultimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases.
Not available
S-EPMC3756526 | biostudies-literature
UnknownIdentification of a Conserved Interface of Human Immunodeficiency Virus Type 1 and Feline Immunodeficiency Virus Vifs with Cullin 5.
Not available
S-EPMC5827384 | biostudies-literature
UnknownRbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors.
Not available
S-EPMC3851519 | biostudies-literature
UnknownCullin 5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF.
Not available
S-EPMC10641258 | biostudies-literature
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