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MetabolomicsMetabolomic Sequencing of Cell-Free Supernatant from Bacillus strain 541

The 4-6 minute fraction from the HPLC fractionation of the bacterial culture supernatant of porcine-derived probiotic Bacillus strain 541.

2025-09-08 | MTBLS12956 | MetaboLights
MetabolomicsDetection of metabolites in the supernatant of Lacticaseibacillus paracasei NCU-21
To investigate the important metabolites responsible for the antitumor activity of L. paracasei NCU-21, LC-MS/MS were employed for metabolomic analysis of the culture supernatant from L. paracasei NCU-21.
2026-04-02 | MTBLS14209 | MetaboLights
MetabolomicsMetabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
In vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to be more biologically relevant, or to optimise growth, is traditionally a laborious task. Emerging metabolomics technology enables rapid evaluation of ...
2015-05-14 | MTBLS49 | MetaboLights
MetabolomicsUntargeted LC-MS metabolomics of in vitro cultured Rothia mucilaginosa supernatant and pellet samples
This study reports untargeted LC-MS metabolomics data from in vitro culture of Rothia mucilaginosa (BNCC363031). A total of 13 biological samples were analyzed, including culture supernatant samples (S1-S5), bacterial pellet samples (B1-B5), and uninoculated medium controls (M1-M3). Data were acquir...
2026-10-06 | MTBLS14792 | MetaboLights
MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
MetabolomicsTargeted LC-MS/MS metabolomics of in vitro cultured Rothia mucilaginosa supernatant (tryptophan and short-chain fatty acid panels)
Targeted LC-MS/MS (MRM) metabolomics of in vitro cultured Rothia mucilaginosa:a tryptophan-pathway panel and a short-chain fatty acid panel comparing culture supernatant with medium controls. Raw mzML files are deposited.
2026-10-06 | MTBLS15044 | MetaboLights
MetabolomicsMetabolomics analysis of Streptomyces sp. 30177 in response to Sphingomonas sp. 06703 supernatant
This study investigated the metabolomic response of Streptomyces sp. 30177 to cell-free supernatant of Sphingomonas sp. 06703. Untargeted LC-MS metabolomics was performed to identify differentially regulated metabolites.
2026-07-30 | MTBLS15203 | MetaboLights
MetabolomicsMetabolomics analysis of Streptomyces sp. 30177 in response to Sphingomonas sp. 06703 supernatant
This study investigated the metabolomic response of Streptomyces sp. 30177 to cell-free supernatant of Sphingomonas sp. 06703. Untargeted LC-MS metabolomics was performed to identify differentially regulated metabolites and pathways involved in metabolic regulation and stress response.
2026-07-23 | MTBLS14907 | MetaboLights
MetabolomicsLactobacillus rhamnosus GG (LGG) exhibits inhibitory effects against non-small cell lung cancer (NSCLC) and alleviates the adverse effects associated with gefitinib_Metabolite study of culture medium supernatant

After screening the bacteria both in vivo and in vitro, it was found that a certain candidate strain could significantly inhibit non-small cell lung cancer when combined with the drug gefitinib and alleviate the side effects of gefitinib. Next, the mechanis...

2026-09-03 | MTBLS13843 | MetaboLights
MetabolomicsMetabolomic signatures in blastocyst spent culture medium as noninvasive predictors of live birth: a pilot study

Research Question: Can metabolomic profiling of blastocyst spent culture medium (SCM) serve as a non-invasive tool to predict live birth?

Design: This pilot study investigated the association between metabolite profiles in SCM and clinical outcomes following single blastocyst transfer. Seve...

2026-02-13 | MTBLS13898 | MetaboLights
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