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ProteomicsAKT1 confers tumor resistance to cuproptosis by phosphorylating FDX1
Cuproptosis, a recently defined copper-dependent cell death, remains largely unexplored in tumor therapies, particularly in breast cancer. Our study demonstrates that triple-negative breast cancer (TNBC) bears a relative elevated copper levels and exhibit resistance to cuproptosis. Mechanistically, ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058176 | Pride
Cuproptosis 
ProteomicsProteomics revealed the crosstalk between copper stress and cuproptosis
As an essential micronutrient element in organisms, copper controls a host of fundamental cellular functions. Recently, copper-dependent cell growth and proliferation have been defined as "cuproplasia". Conversely, “cuproptosis” represents copper-dependent cell death, a nonapoptotic manner. So far, ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-17 | PXD037278 | Pride
Human Cuproptosis Copper stress Cancer 
TranscriptomicsIdentification of Cuproptosis-related genes in Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent hepatic pathology worldwide. However, the precise molecular mechanisms for NAFLD are still not sufficiently explained. Recently, a new mode of cell death (cuproptosis) is found. However, the relationship between NAFLD and cuproptosis rem...
ORGANISM(S): Mus musculus 
2023-04-30 | E-MTAB-11980 | biostudies-arrayexpress
ProteomicsSIRT5-Mediated FDX1 Desuccinylation Confers Cuproptosis Resistance in Lung cancer
Cuproptosis, a copper-dependent cell death process induced by excessive copper, represents an emerging therapeutic strategy in oncology. However, tumor specific molecular pathways regulating this process remain poorly defined. Here, we demonstrate that copper levels are elevated in lung adenocarcino...
ORGANISM(S): Homo Sapiens 
2026-04-17 | PXD077292 |
GenomicsIdentification of Cuproptosis-related genes in Nonalcoholic Fatty Liver Disease
Identification of Cuproptosis-related genes in Nonalcoholic Fatty Liver Disease
PRJEB54890 | ENA
ProteomicsSystematic and Quantitative Investigation of Newly Synthesized Proteins Reveals Distinct Ion Homeostasis and Mitochondrial Changes between Cuproptosis and Ferroptosis in Human Cells
To better understand ferroptosis and cuproptosis, here we systematically and quantitatively analyzed newly synthesized proteins (NSPs), which reflect rapid changes in gene expression during cell death without the interference from the existing proteins. Integrating metabolic labeling with multiplexe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-11-13 | MSV000099889 | MassIVE
TranscriptomicsDysregulated Wnt signaling confers resistance to cuproptosis in cancer cells
Cuproptosis is characterized by the aggregation of lipoylated components of the tricarboxylic acid cycle and subsequent loss of iron-sulfur cluster proteins as a unique copper-dependent form of regulated cell death. Dysregulation of copper homeostasis and resulting cuproptosis induction is an emergi...
ORGANISM(S): Homo sapiens 
2023-11-21 | GSE248083 | GEO
TranscriptomicsDysregulated Wnt signaling confers resistance to cuproptosis in cancer stem cells
Cuproptosis is characterized by the aggregation of lipoylated components of the tricarboxylic acid cycle and subsequent loss of iron-sulfur cluster proteins as a unique copper-dependent form of regulated cell death. Dysregulation of copper homeostasis and resulting cuproptosis induction is an emergi...
ORGANISM(S): Homo sapiens 
2023-11-21 | GSE248084 | GEO
GenomicsNitrofurantoin Enhances Cuproptosis Sensitivity in Cancer Cells Through SLC11A2-Dependent Copper Homeostasis
Nitrofurantoin Enhances Cuproptosis Sensitivity in Cancer Cells Through SLC11A2-Dependent Copper Homeostasis
PRJNA1518856 | ENA
GenomicsIsocitrate Dehydrogenase 1 Primes Group-3 Medulloblastomas For Cuproptosis
Isocitrate Dehydrogenase 1 Primes Group-3 Medulloblastomas For Cuproptosis
PRJNA1169346 | ENA
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