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ProteomicsMutagenesis of Key Phosphodiesterases in Toxoplasma gondii Demonstrates the Plasticity and Therapeutic Potential of Cyclic Nucleotide Signaling
Cyclic nucleotide signaling is pivotal to the asexual growth of T. gondii; however, little do we know about its counter-regulation in this parasite. We identified 18 phosphodiesterase (PDE1-18) enzymes, most of which form apicomplexan-specific clades and lack typical regulatory motifs found in mamma...
ORGANISM(S): Cellular Organisms 
2023-02-22 | PXD032173 | JPOST Repository
TranscriptomicsGene expression in mouse retinas with cone cyclic nucleotide gated channel deficiencies
The cone photoreceptor cyclic nucleotide-gated (CNG) channel is essential for central and color vision and visual acuity. Mutations in the channel subunits CNGA3 and CNGB3 are associated with achromatopsia and cone dystrophy. We investigated the gene expression profiles in mouse retina with CNG ch...
ORGANISM(S): Mus musculus 
2013-07-03 | E-GEOD-40982 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics reveals bovine viral diarrhea virus infection reprogram host nucleotide and amino acid metabolism in MDBK Cells

Bovine viral diarrhea virus (BVDV) is a highly adapted intracellular parasite that depends entirely on the host cell's metabolic resources and energy for the synthesis of viral components. However, the mechanisms by which BVDV remodels host lipid metabolism remain unclear. In this study, we explo...

2025-10-12 | MTBLS13126 | MetaboLights
ProteomicsStructural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel (LiP-MS)
The aim of the project was to characterize structural changes that occur on the rod cyclic nucleotide-gated channel upon interaction with calmodulin (CaM) directly in the native membrane.
ORGANISM(S): Bos taurus (Bovine) 
2023-04-06 | PXD038768 | Pride
Limited proteolysis coupled mass spectrometry Structural proteomics Lip-ms 
TranscriptomicsAnalysis of ToxT regulon in Vibrio cholerae El Tor
Using a combination of ChIP-seq and RNA-seq we show that ToxT regulates expression of the small RNA TarB. TarB modulates the expression level of the transcriptioanl repressor VC0177. VC0177 controls expression of several genes including VC0179. The function of the Vibrio 7th pandemic island-1 (VSP-1...
ORGANISM(S): Vibrio cholerae O1 str. C6706 
2012-04-13 | E-GEOD-36373 | biostudies-arrayexpress
GenomicsTranscriptional profiling to elucidate processes regulated by 2',3'-cyclic nucleotide monophosphates in Escherichia coli
Transcriptional profiling to elucidate processes regulated by 2',3'-cyclic nucleotide monophosphates in Escherichia coli
PRJNA472952 | ENA
GenomicsTherapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
PRJNA699002 | ENA
TranscriptomicsRibonuclease L and Metal-Ion-Independent Endoribonuclease Cleavage Sites in Host and Viral RNAs
We used 2', 3'-cyclic phosphate cDNA synthesis and Illumina sequencing to identify and quantify metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs. To make cDNA libraries, we exploited the 2’, 3’-cyclic phosphate at the end of RNA fragments produced by RNase L and other met...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-52489 | biostudies-arrayexpress
ProteomicsCyclic AMP signalling controls key components of malaria parasite host cell invasion machinery
Cyclic nucleotides are important signalling molecules across evolution, but their roles in malaria parasites are poorly understood. We have investigated the role of cAMP in asexual blood stage development of Plasmodium falciparum through conditional disruption of adenylyl cyclase (ACβ) and its downs...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2019-05-14 | PXD012143 | Pride
Host cell invasion Malaria Camp‐dependent protein kinase Adenylyl cyclase β Orbitrap fusion lumos Cyclic nucleotide signalling Ama1 Plasmodium falciparum 
TranscriptomicsTranscriptional profiling to elucidate processes regulated by 2',3'-cyclic nucleotide monophosphates in Escherichia coli
The impact of 2',3'-cyclic nucleotide monophosphates (2',3'-cNMPs) on global gene expression in E. coli was investigated by heterologous expression of a 2',3'-cyclic nucleotide phosphodiesterase (CNPase), which reduces intracellular 2',3'-cNMP levels.
ORGANISM(S): Escherichia coli BW25113 
2021-05-23 | GSE114871 | GEO
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