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Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
TranscriptomicsTranscription profiling by array of human non-activated MM6 cells with cyclin T1 knockdown
Cyclin T1-dependent genes in LPS-activated MM6 cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II ...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10738 | biostudies-arrayexpress
ProteomicsAMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
The AMP-activated protein kinase (AMPK) is a master sensor of the cellular energy status and is crucial for the adaptive response to limited energy availability. AMPK is implicated in the regulation of many cellular processes, including autophagy. However, the precise mechanisms by which AMPK contro...
ORGANISM(S): Homo sapiens (Human) 
2020-02-17 | PXD009968 | Pride
Human Autophagy Nanolc-msms Phosphorylation 
TranscriptomicsTranscription profiling by array of human LPS-activated MM6 cells with Cyclin D1 knockdown
Cyclin T1-dependent genes in LPS-activated MM6 cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II e...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10234 | biostudies-arrayexpress
TranscriptomicsComparison of Normal Prostate Fibroblasts Overexpressing Cyclin D1 and Carcinoma Associated Fibroblasts
The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G1 to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 prote...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-6936 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MM6 cells response to cyclin T1
This SuperSeries is composed of the following subset Series:; GSE10232: CTDG in PMA-activated Jurkat cells; GSE10233: CTDG in PMA-activated MM6 cells; GSE10234: CTDG in LPS-activated MM6 cells; GSE10737: CTDG in non-activated Jurkat cells; GSE10738: CTDG in non-activated MM6 cells; GSE10739: LPS and...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-11462 | biostudies-arrayexpress
TranscriptomicsCTDG in PMA-activated MM6 cells
Cyclin T1-dependent genes in PMA-activated MM6 cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II e...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10233 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human PMA-activated Jurkat cells
Cyclin T1-dependent genes in activated Jurkat cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II el...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10232 | biostudies-arrayexpress
ProteomicsCyclin Y is expressed in platelets and modulates integrin outside-in signaling
Diabetes is associated with platelet hyperactivation and enhanced risk of thrombosis development. We have previously shown that calpain inhibition stabilizes the platelet proteome in diabetic patients. However, a global proteome analysis comparing platelets from healthy donors and from diabetic pati...
ORGANISM(S): Homo sapiens (Human) 
2021-05-31 | PXD021271 | Pride
Proteomics Platelets Diabetes 
ProteomicsStructural basis of the cyclin Y/14-3-3 protein-mediated activation of CDK16
Cyclin-dependent protein kinase 16 (CDK16) regulates both physiological and pathological processes, including autophagy, spermatogenesis and cancer. Unlike other CDKs, CDK16 is regulated by an unclear mechanism involving phosphorylated cyclin Y (CCNY) in complex with 14-3-3 proteins rather than CCNY...
ORGANISM(S): Escherichia coli 
2026-03-31 | PXD074528 | Pride
Structure Cdk16 Cyclin y/14-3-3 
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