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ProteomicsStructural basis of the cyclin Y/14-3-3 protein-mediated activation of CDK16
Cyclin-dependent protein kinase 16 (CDK16) regulates both physiological and pathological processes, including autophagy, spermatogenesis and cancer. Unlike other CDKs, CDK16 is regulated by an unclear mechanism involving phosphorylated cyclin Y (CCNY) in complex with 14-3-3 proteins rather than CCNY...
ORGANISM(S): Escherichia coli 
2026-03-31 | PXD074528 | Pride
Structure Cdk16 Cyclin y/14-3-3 
ProteomicsStructural basis of the cyclin Y/14-3-3 protein-mediated activation of CDK16
Cyclin-dependent protein kinase 16 (CDK16) regulates both physiological and pathological processes, including autophagy, spermatogenesis and cancer. Unlike other CDKs, CDK16 is regulated by an unclear mechanism involving phosphorylated cyclin Y (CCNY) in complex with 14-3-3 proteins rather than CCNY...
ORGANISM(S): Homo sapiens (Human) 
2026-03-25 | PXD064389 | Pride
Cdk16 Cyclin-dependent protein kinase Ccny Cyclin y 14-3-3 protein 
ProteomicsStructural basis of the cyclin Y/14-3-3 protein-mediated activation of CDK16
Cyclin-dependent protein kinase 16 (CDK16) regulates both physiological and pathological processes, including autophagy, spermatogenesis and cancer. Unlike other CDKs, CDK16 is regulated by an unclear mechanism involving phosphorylated cyclin Y (CCNY) in complex with 14-3-3 proteins rather than CCNY...
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PXD070539 | Pride
Hydrogen-deuterium exchange Cyclin y Cyclin-dependent protein kinase 16 14-3-3 proteins 
TranscriptomicsLack of G1 cyclin arrest cell cycle synchronization time-course microarray in Glucose
Lack of G1 cyclin arrest cln1,2,3-delta MET3pr-CLN2 cells Cell cycle syncronization time-course microarray in Glucose. Time-course experiment. Samples are hybridized onto the first timepoint.
ORGANISM(S): Saccharomyces cerevisiae 
2011-06-11 | E-GEOD-29800 | biostudies-arrayexpress
TranscriptomicsPho85, Pcl1, and Hms1 Signaling Governs Candida albicans Morphogenesis Induced by Elevated Temperature or Hsp90 Compromise [mRNA]
The capacity to sense and transduce temperature signals pervades all aspects of biology, and temperature exerts powerful control over the development and virulence of diverse pathogens. In the leading fungal pathogen of humans, Candida albicans, temperature has a profound impact on morphogenesis, a ...
ORGANISM(S): Candida albicans 
2012-03-20 | E-GEOD-34255 | biostudies-arrayexpress
TranscriptomicsShp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430A_2 array]
In this study, we have used techniques from cell biology, biochemistry, and genetics to investigate the role of the tyrosine phosphatase Shp2 in tumor cells of MMTV-PyMT mouse mammary glands. Genetic ablation or pharmacological inhibition of Shp2 induces senescence, as determined by the activation o...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-50516 | biostudies-arrayexpress
TranscriptomicsShp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430_2 array]
In this study, we have used techniques from cell biology, biochemistry, and genetics to investigate the role of the tyrosine phosphatase Shp2 in tumor cells of MMTV-PyMT mouse mammary glands. Genetic ablation or pharmacological inhibition of Shp2 induces senescence, as determined by the activation o...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-50517 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of DYRK1A-deficient (CKO) pre-B and pre-T cells
Pre-B and pre-T lymphocytes must orchestrate a transition from a highly proliferative state to a quiescent one during development. Cyclin D3 is essential for these cells’ proliferation, but little is known about its post-translational regulation at this stage. Here, we show that the dual specificity...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-67052 | biostudies-arrayexpress
UnknownStructure and inhibitor specificity of the PCTAIRE-family kinase CDK16.
Not available
S-EPMC5317395 | biostudies-literature
TranscriptomicsThe role of PCNA ubiquitylation during unperturbed genome replication in S.pombe
To establish if PCNA ubiquitylation affects the DNA replication kinetics of specific loci, we compared rates of DNA replication across the genome between rad18+ and rad18-delta cells using the BrdU-IP sequencing method. We mapped BrdU-incorporation at 300-bp resolution and subsequent informatics an...
ORGANISM(S): Schizosaccharomyces pombe 
2017-05-12 | E-GEOD-70033 | biostudies-arrayexpress
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