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MetabolomicsA cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
Digoxin extracted from the foxglove plant is a widely prescribed natural product for treating heart failure. It is listed as an essential medicine by the World Health Organization. However, how the foxglove plant synthesizes digoxin is mostly unknown, especially the cytochrome P450 sterol side chain...
2025-07-03 | MTBLS7993 | MetaboLights
MetabolomicsAssessing the Feasibility of In Vitro Assays in Combination with Biological Matrices to Screen for Endogenous CYP450 Phenotype Biomarkers Using an Untargeted Metabolomics Approach—A Proof of Concept Study

Cytochrome P450 (CYP) enzymes are crucial for drug metabolism, yet inter-individual variability in their activity remains a significant clinical challenge. Current phenotyping methods are often impractical or even impossible, particularly in forensic toxicology and vulnerable populations. This pr...

2025-12-12 | MTBLS13325 | MetaboLights
ProteomicsLong term effects of ethanol intake on the CYP450 enzyme system in the liver of AFLD rats
Alcoholic fatty liver disease (AFLD) is a liver disease closely related to long-term alcohol consumption. Although it is known that liver microsomal cytochrome P450 enzyme (CYP450) plays a crucial role in metabolizing alcohol and various exogenous compounds, the specific mechanism by which alcohol a...
ORGANISM(S): Mus Musculus 
PXD063375 |
ModelsGonzalez2021 - QSAR Prediction Model for CYP450 enzymes Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP450 activity and whether the compounds are a substrate for the CYP450 enzymes. The data used to build these models is publicly available at PubChem (AID1645840, AID1645841, AID1645842). The tested cyps include CYP2C9, CYP2D6 and CYP3A...
2024-05-10 | MODEL2404160004 | BioModels
Machine Learning Model Ersilia 
ProteomicsIntroducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment
he Nanopig™ model is an emerging non-rodent platform for (bio)pharmaceutical safety assessment, with potential advantages for translational research. Here, we report initial characterization results using whole genome sequencing (WGS) and tissue-based proteomics, focusing on drug metabolism and immu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-10-08 | PXD068793 | Pride
Hepatic cyp450 Preclinical model Nanopig Whole genome sequencing Proteomics 
ProteomicsProteomic Consequences of the Deletion of Cytochrome P450 (CYP450) Reductase in Mice
Microsomal cytochrome P450 (CYP450) reductase enzymes play a major role in drug and xenobiotic metabolism. Mice which are deficient in hepatic CYP450 reductase serve as excellent models in understanding CYP450 drug metabolism and alterations in the underlying biology. A reversed-phase nano-bore UPLC...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-26 | PXD024420 | Pride
Proteomics  cytochrome p450  lipid metabolism  bile acids  glutathione Tca cycle. 
ProteomicsIntroducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment
The Nanopig™ model is an emerging non-rodent platform for (bio)pharmaceutical safety assessment, with potential advantages for translational research. Here, we report initial characterization results using whole genome sequencing (WGS) and tissue-based proteomics, focusing on drug metabolism and imm...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-10-08 | PXD069209 | Pride
Nanopig Tissue Plasma Lc-msms 
UnknownThe reference liver-CYP450 and UGT enzymes in healthy donor and metastatic livers: the impact of genotype.
Not available
S-EPMC8786777 | biostudies-literature
UnknownInteraction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin.
Not available
S-EPMC3513969 | biostudies-literature
UnknownDocking studies of piperine - iron conjugate with human CYP450 3A4.
Not available
S-EPMC3669784 | biostudies-literature
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