Sort   by:  
 Page size 
ProteomicsCysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair
Tissue repair after myocardial infarction (MI) is guided by incompletely defined autocrine and paracrine-acting proteins. Deciphering these signals and their upstream triggers is essential when considering infarct healing as a therapeutic target. Searching for previously unknown growth factors invol...
ORGANISM(S): Homo sapiens (Human) 
2023-11-30 | PXD045013 | Pride
Phosphoproteomics Endothelial cells Cysteine-rich with egf-like domains 2 Creld2 Myocardial infarction Tissue repair 
UnknownCysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair.
Not available
S-EPMC11358006 | biostudies-literature
UnknownEndoplasmic reticulum (ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) is an important mediator of BMP9-regulated osteogenic differentiation of mesenchymal stem cells.
Not available
S-EPMC3760886 | biostudies-literature
UnknownDefinition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits.
Not available
S-EPMC58703 | biostudies-literature
UnknownThe evolution of extracellular fibrillins and their functional domains.
Not available
S-EPMC3306419 | biostudies-literature
ProteomicsSelective activation of PERK signaling mediates fibroblast education and tumor progression by a CRELD2-dependent mechanism
It is now well-accepted that cancers co-opt the microenvironment to support their growth. However, the molecular mechanisms underlying cancer-microenvironment interactions remain poorly defined. We have found that Rho-associated kinase (ROCK) activity in the epithelial component of mammary tumors se...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-27 | PXD018253 | Pride
Cancer progression Integrated stress response (isr) Unfolded protein response 25 (upr) Perk Cancer-associated fibroblasts (cafs) Breast cancer Endoplasmic reticulum (er)stress Rock 26 extracellular matrix Tumor microenvironment 
TranscriptomicsCreld2 function during unfolded protein response is essential for liver metabolism homeostasis
The unfolded protein response (UPR) is associated with the metabolic function of the liver, yet it is not well understood how endoplasmic reticulum (ER) disturbance might influence metabolic homeostasis. Here, we describe the physiological function of the Cysteine-rich with EGF-like domains 2 (Creld...
ORGANISM(S): Mus musculus 
2021-08-18 | GSE143185 | GEO
TranscriptomicsTranscriptional profiling of mouse molar and incisor tooth organoids
Organoid models provide powerful tools to study tissue biology and development in a dish. Here, we established first-time organoid models from early-postnatal (postnatal day 7) mouse molar and incisor, capable of differentiation toward ameloblast-like cells in vitro. To more in detail characterise ...
ORGANISM(S): Mus musculus 
2023-04-19 | E-MTAB-12557 | biostudies-arrayexpress
TranscriptomicsThe transcriptomic effect of induced LRIG1 expression in NPC cells
As LRIG1 known to be a negative regulator of EGFR, we postulate that restored LRIG1 expression will change the transcription profile through the regulation of EGFR as well as its downstream signal cascades. Thus, we conducted a time-course microarray study to examine the effect of restored LRIG1 exp...
ORGANISM(S): Homo sapiens 
2013-05-02 | E-GEOD-37349 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of intestinal epithelial organoids derived from human fetal duodenum
Here, we used single-cell RNA-sequencing (scRNA-seq) to profile intestinal epithelial only organoids (also known as enteroids) from human fetal duodenum after one passage of in vitro growth. Organoids were grown in the standard 25% LWRN media with either 100 ng/ml of EGF or 1 ng/ml of EREG added.
ORGANISM(S): Homo sapiens 
2022-07-17 | E-MTAB-11912 | biostudies-arrayexpress
Sort   by:  
 Page size