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TranscriptomicsActivation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells
After immunization or infection, activation-induced cytidine deaminase (AID) initiates diversification of immunoglobulin (Ig) genes in B cells, introducing mutations within the antigen binding V regions (somatic hypermutation, SHM) and double-strand DNA breaks (DSBs) into switch (S) regions, leading...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-24827 | biostudies-arrayexpress
GenomicsGenome wide localization of Activation induced cytidine deaminase (AID), Spt5, and RNA Polymerase II (PolII) in mouse
Activation induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody genes. Off-target lesions can activate oncogenes or cause chromosome translocations. Despite its importance in these key transactions little is kn...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-24178 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human BCR-ABL1-transformed acute lymphoblastic leukemia cells reveals Activation-induced cytidine deaminase acts as a mutator
The Philadelphia chromosome (Ph) encoding the oncogenic BCR-ABL1 kinase defines a subset of ALL with a particularly unfavorable prognosis. Acute lymphoblastic leukemia (ALL) cells are derived from B cell precursors in most cases and typically carry rearranged immunglobulin heavy chain (IGH) variable...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7182 | biostudies-arrayexpress
TranscriptomicsEpigenetic targeting of activation-induced cytidine deaminase
Precisely how AID is recruited to these off-target sites is not entirely understood. To gain further insight into how AID selects its targets we compared AID-mediated translocations in two different cell types, B cells and mouse embryonic fibroblasts (MEFs). AID targets a distinct set of hotspots in...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-61523 | biostudies-arrayexpress
ClinicalA study of pharmacokinetic analysis of capecitabine and cytidine deaminase activity
Interventions: Blood samples(10 points) are collected after the first administration of capecitabine for pharmacokinetic analysis and cytidine deaminase activity measurement. Primary outcome(s): To evaluate the correlation AUC of 5-DFUR/AUC of 5-DFCR ratio and cytidine deaminase activity. Study Desi...
2634538 | ecrin-mdr-crc
GenomicsAPOBEC Cytidine Deaminase Mutagenesis Pattern is Widespread in Human Cancers
APOBEC Cytidine Deaminase Mutagenesis Pattern is Widespread in Human Cancers
PRJNA226256 | ENA
GenomicsWhole genome sequencing analysis of evolved E.coli
We created a mutator protein. The mutator, was prepared by fusing a PmCDA1 (Petromyzon marinus Cytidine DeAminase) and E.coli RNA polymerase alpha subunit(EcoRNAP alpha). After 120 cycles, whole genome sequencing was performed on the wild type and evolved sample. After characterization of the mutati...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2021-05-03 | E-MTAB-10368 | biostudies-arrayexpress
GenomicsBase editing with a Cpf1–cytidine deaminase fusion
Base editing with a Cpf1–cytidine deaminase fusion
PRJNA432936 | ENA
ProteomicsA potent cytidine deaminase biodegrader sensitises cancer cells to deoxycytidine analogue-based chemotherapies
Deoxycytidine analogues (dC) are chemotherapy agents used to treat a range of solid and blood cancers. However, their clinical efficacy is often limited by resistance mechanisms. Cytidine deaminase (CDA) plays a key role of this resistance by deaminating dC analogues into inactive metabolites. Altho...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD065390 | Pride
Targeted protein degradation Cytarabine Cytidine deaminase Chemotherapy resistance Single domain antibody Lung cancer Biodegrader Pancreatic cancer Gemcitabine 
GenomicAn APOBEC Cytidine Deaminase Mutagenesis in Human Cancers

Reprinted from Roberts et al. "An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers", Nature Genetics, 45:970-976, 2013, with permission of Nature Publishing Group:

Recent studies indicate that a subclass of APOBEC cytidine deaminases, which convert cytosi...

phs000677 | dbGaP
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