Sort   by:  
 Page size 
MetabolomicsUntargeted metabolomics for triaging of cytochrome b inhibitors during Chagas’ disease drug discovery

Chagas’ disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is a potentially fatal condition for which new treatments are urgently needed. Due to the lack of validated drug targets, phenotypic screening followed by target deconvolution is the dominant approach in Chagas’ d...

2026-01-12 | MTBLS13510 | MetaboLights
MetabolomicsA cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
Digoxin extracted from the foxglove plant is a widely prescribed natural product for treating heart failure. It is listed as an essential medicine by the World Health Organization. However, how the foxglove plant synthesizes digoxin is mostly unknown, especially the cytochrome P450 sterol side chain...
2025-07-03 | MTBLS7993 | MetaboLights
ProteomicsComparison of Partially Denatured Cytochrome c Structural Ensembles in Solution and Gas Phases Using Cross-Linking Mass Spectrometry
Datasets in the publication Comparison of Partially Denatured Cytochrome c Structural Ensembles in Solution and Gas Phases Using Cross-Linking Mass Spectrometry
ORGANISM(S): Equus Caballus 
2025-05-22 | PXD064154 | JPOST Repository
TranscriptomicsTranscription profiling of mouse models with liver-specific deletion or global hypomorphic expression of the NADPH-cytochrome P450 reductase gene to study molecular mechanisms for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
NADPH-cytochrome P450 reductase (CPR) is important for the functions of many enzymes, such as microsomal cytochrome P450 (P450) monooxygenases and heme oxygenases. Two mouse models with deficient CPR expression in adults were recently generated in this laboratory: liver-Cpr-null (with liver-specific...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2362 | biostudies-arrayexpress
TranscriptomicsEvidence for a key role of cytochrome bo3 oxidase in respiratory energy metabolism of Gluconobacter oxydans
The obligatory aerobic acetic acid bacterium Gluconobacter oxydans oxidizes a variety of substrates in the periplasm by membrane-bound dehydrogenases, which transfer the reducing equivalents to ubiquinone. Two quinol oxidases, cytochrome bo3 and cytochrome bd, then catalyze transfer of the electrons...
ORGANISM(S): Gluconobacter oxydans 621H 
2013-07-26 | E-GEOD-47782 | biostudies-arrayexpress
TranscriptomicsInfluence of oxygen limitation, absence of the cytochrome bc1 complex and low pH on global gene expression in Gluconobacter oxydans 621H using DNA microarray technology
The genome-wide transcriptional responses of the strictly aerobic -proteobacterium Gluconobacter oxydans 621H to oxygen limitation, to the absence of the cytochrome bc1 complex, and to low pH were studied using DNA microarray analyses. Oxygen limitation caused expression changes of 486 genes, repres...
ORGANISM(S): Gluconobacter oxydans 621H 
2012-03-23 | E-GEOD-34294 | biostudies-arrayexpress
ProteomicsArabidopsis thaliana Cytochrome c Novel Partners Identification by LTQ
Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, it is necessary for development and for the hypersensitive response to stress or pathogenic infection. A common feature to programmed cell death among organisms is the mitochondria-to-cyt...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2013-11-11 | PXD000280 | Pride
Arabidopsis thaliana Cytochrome c Programmed cell death H2o2 Protein-protein interactions 
ProteomicsBiotransformation of efavirenz and proteomic analysis of P450s and UGTs in human, mouse, and macaque brain-derived in vitro systems
Antiretroviral drugs such as efavirenz (EFV) are essential to combat HIV infection in the brain, but little is known about how these drugs are metabolized locally. In this study, the cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT)-dependent metabolism of EFV was probed in brain microsom...
ORGANISM(S): 9606 
2022-10-24 | MSV000090576 | MassIVE
TranscriptomicsChip-chip analysis of C. glutamicum SigC
Bacteria modify expression of different types of terminal oxidase in response to oxygen availability. Corynebacterium glutamicum, a facultative anaerobic bacterium in Actinobacteria, possesses aa3-type cytochrome c oxidase and cytochrome bd-type quinol oxidase, the latter of which is induced upon ox...
ORGANISM(S): Corynebacterium glutamicum 
2016-08-22 | E-GEOD-72452 | biostudies-arrayexpress
ProteomicsCytochrome c Lysine Acetylation Regulates Cellular Respiration and Cell Death in Ischemic Skeletal Muscle
Cytochrome c (Cytc) is essential for mitochondrial respiration and apoptosis. Tissue specific post-translational modifications of Cytc play an important regulatory role in these processes. Here, we describe a new acetylation site, lysine 39, which was mapped in ischemic porcine skeletal muscle. Reco...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-07-10 | PXD040915 | Pride
Acetylation Cytochrome c Ischimic muscle 
Sort   by:  
 Page size