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MetabolomicsAn Atlas of Ferroptosis-induced Secretomes promotes Macrophage priming
Cells undergoing regulated necrosis systemically communicate with the immune system via release of protein and non-protein secretomes. Ferroptosis is a recently described iron-dependent type of regulated necrosis driven by massive lipid peroxidation. While membrane rupture occurs during ferroptosis,...
2025-03-04 | MTBLS9798 | MetaboLights
GenomicsSynergistic Activation of Inflammatory Cytokine Genes by Priming of Regulatory DNA Elements for Increased Transcription in Response to TLR Signaling
Synergistic activation of inflammatory cytokine genes by IFN-gamma and TLR signaling is important for innate immunity and inflammatory disease pathogenesis, but underlying mechanisms are not known. By obtaining over three billion bases of sequence from chromatin immunoprecipitated DNA, we generated ...
ORGANISM(S): Homo sapiens 
2013-09-20 | E-GEOD-43036 | biostudies-arrayexpress
ProteomicsCytokine Priming Enhances the Antifibrotic Effects of Mesenchymal Stromal Cells Conditioned Medium Via Fibrogenic Myofibroblasts Elimination and Extracellular Matrix Degradation.
Fibrosis is a pathological scarring process characterized by persistent myofibroblasts activation with excessive accumulation of extracellular matrix (ECM). Fibrotic disorders represent an increasing burden of disease-associated morbidity and mortality worldwide for which there are limited therapeut...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051586 | Pride
Msc Myofibroblasts Multipotent mesenchymal stromal cells Fibrosis Conditioned medium Extracellular matrix 
GenomicsPriming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors
Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors
PRJNA773956 | ENA
TranscriptomicsAtherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells
Single-cell RNA sequencing revealed a dysregulated myeloid immune response with hyperinflammatory and immunosuppressive features in patients with ASCVD and moderate COVID-19. Assay for Transposase-Accessible Chromatin sequencing and in-vitro experiments with isolated monocytes infected with SARS-CoV...
ORGANISM(S): Homo sapiens 
2025-01-15 | E-MTAB-16472 | biostudies-arrayexpress
MetabolomicsSimilar, but different: structurally related azelaic acid and hexanoic acid trigger differential metabolomic and transcriptomic responses in tobacco cells
BACKGROUND: Plants respond to various stress stimuli by activating an enhanced broad-spectrum defensive ability. The development of novel resistance inducers represents an attractive, alternative crop protection strategy. In this regard, hexanoic acid (Hxa, a chemical elicitor) and azelaic acid (Aza...
2018-10-17 | MTBLS559 | MetaboLights
GenomicsIL-33 priming and antigenic stimulation synergistically promote the transcription of proinflammatory cytokine and chemokine genes in human skin mast cells
IL-33 priming and antigenic stimulation synergistically promote the transcription of proinflammatory cytokine and chemokine genes in human skin mast cells
PRJNA807669 | ENA
GenomicsCytokine Priming Enhances the Antifibrotic Effects of Mesenchymal Stromal Cells Conditioned Medium Via Fibrogenic Myofibroblasts Elimination and Extracellular Matrix Degradation.
Cytokine Priming Enhances the Antifibrotic Effects of Mesenchymal Stromal Cells Conditioned Medium Via Fibrogenic Myofibroblasts Elimination and Extracellular Matrix Degradation.
PRJNA1105607 | ENA
TranscriptomicsComparative analysis of human and mouse transcriptomes of Th17 cell priming.
Uncontrolled Th17 cell activity is associated with cancer and autoimmune and inflammatory diseases. To validate the potential relevance of mouse models of targeting the Th17 pathway in human diseases we used RNA sequencing to compare the expression of coding and non-coding transcripts during the pri...
ORGANISM(S): Homo sapiens 
2016-04-07 | E-GEOD-52260 | biostudies-arrayexpress
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, SCL/TAL1 and FL...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-49664 | biostudies-arrayexpress
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