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ProteomicsTime-course Activation of Human Peripheral Blood Eosinophils by Cytokines
Activated eosinophils contribute to airway dysfunction and tissue remodeling in asthma, and thus are considered an important factor in asthma pathology. We report here comparative proteomic and phosphoproteomic changes upon activation of eosinophils using eight cytokines individually and in selected...
ORGANISM(S): Homo sapiens (Human) 
2017-12-19 | PXD004043 | Pride
Proteomics Asthma Mass spectrometry Activation Flow cytometry Cytokines Phosphoproteomics Eosinophils 
TranscriptomicsThe human pancreatic islet transcriptome: impact of pro-inflammatory cytokines
We have used RNA-seq to identify transcripts, including splice variants, expressed in human islets of Langerhans under control condition or following exposure to the pro-inflammatory cytokines interleukin-1β (IL-1β) and interferon-γ (IFN-γ). A total of 29,776 transcripts were identified as expressed...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-35296 | biostudies-arrayexpress
ProteomicsQuantification of cytokines secreted by primary human cells using MRM: evaluation of analytical parameters â?? shotgun secretome data of untreated HUVECs
The determination of secreted proteins may provide highly valuable information about cell functions. While the typical methods for the determination of biologically relevant but low-abundant molecular species still relies on the use of specific antibodies, mass spectrometry-based methods are now gai...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079983 | MassIVE
ProteomicsQuantification of cytokines secreted by primary human cells using MRM: evaluation of analytical parameters â?? shotgun secretome data of inflammatory stimulated HUVECs
The determination of secreted proteins may provide highly valuable information about cell functions. While the typical methods for the determination of biologically relevant but low-abundant molecular species still relies on the use of specific antibodies, mass spectrometry-based methods are now gai...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079982 | MassIVE
ModelsBaker2017 - The role of cytokines, MMPs and fibronectin fragments osteoarthritis
Baker2017 - The role of cytokines, MMPs and fibronectin fragments osteoarthritis This model is described in the article: Mathematical modelling of cytokines, MMPs and fibronectin fragments in osteoarthritic cartilage. Baker M, Br...
2024-09-02 | BIOMD0000000928 | BioModels
ProteomicsProteomic analysis of human microglia cells (HMC3) stimulated with anti-inflammatory cytokines using serum-deprived culture conditions
The immune functions of microglia in the brain are compromised in the presence of tumors that have the ability to “hijack” their pro-inflammatory nature by sending out signals that promote cancer progression. To analyze the tumor-supportive microglia phenotype, human microglia cells (HMC3) were trea...
ORGANISM(S): Homo sapiens (Human) 
2021-10-07 | PXD023163 | Pride
Hmc3 Cytokines Tumor Microglia 
ProteomicsProteomic analysis of human microglia cells (HMC3) stimulated with anti-inflammatory cytokines using serum-enriched culture conditions
The immune functions of microglia in the brain are compromised in the presence of tumors that have the ability to “hijack” their pro-inflammatory nature by sending out signals that promote cancer progression. To analyze the tumor-supportive microglia phenotype, human microglia cells (HMC3) were trea...
ORGANISM(S): Homo sapiens (Human) 
2021-10-06 | PXD023166 | Pride
Hmc3 Cytokines Tumor Microglia 
TranscriptomicsGlobal microRNA profiling of aTC1-6 and bTC1 before and after treatment with cytokines
The study sought to determine the global miRNA profiles of mouse pancreatic cell lines aTC1-6 and bTC1 at steady state and after treatment with a cocktail of pro-inflammatory cytokines (IL1b; IFNg and TNFa) for a time course of 24 and 48 hours. Inflammatory cocktail contains IL1b 50 IU/ml; IFNg 1000...
ORGANISM(S): Mus musculus 
2012-12-18 | E-GEOD-42970 | biostudies-arrayexpress
ProteomicsRed Algae-Derived Mineral Intervention to Counter Pro-inflammatory Activity in Human Colon Organoids
Human colon organoids were maintained in culture medium alone or exposed to lipopolysaccharide with a combination of three pro-inflammatory cytokines (tumor necrosis factor-a, interleukin-1b and interferon-g [LPS-cytokines]) to mimic the environment in the inflamed colon. Untreated organoids and tho...
ORGANISM(S): Homo sapiens (Human) 
2023-06-30 | PXD038941 | Pride
Lps Proteomics Inflammation Cytokines Gut barrier Multi-mineral Colon organoids 
GenomicsImmGen cytokines: Signatures of “common γ-chain” family cytokines
ImmGen cytokines: Signatures of “common γ-chain” family cytokines
PRJNA746283 | ENA
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