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MetabolomicsLysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation

Eosinophils are the predominant immune cells implicated in the pathogenesis of asthma, highlighting the need for strategies to mitigate their effects. While previous studies have indicated a potential relationship between lysosomes and eosinophils, the precise role of lysosomes in eosinophil acti...

2025-09-15 | MTBLS13001 | MetaboLights
TranscriptomicsTranscriptomic response to ex vivo IL33 stimulation of blood eosinophils from mepolizumab- or omalizumab-treated patients
Coding RNA expression of blood eosinophils from mepolizumab- or omalizumab-treated patients stimulated ex vivo with IL-33 for 6 hours and of directly processed non-stimulated blood eosinophils from the same samples (paired design)
ORGANISM(S): Homo sapiens 
2021-12-17 | E-MTAB-10189 | biostudies-arrayexpress
TranscriptomicsTranscriptomics of circulating human eosinophils
Global expression pattern in eosinophils in various conditions such as eosinophilic asthma, hypereosinophilic dermatological diseases, parasitosis and pulmonary aspergillosis. Eosinophil were isolated from peripheral blood by FACS from 4 hypereosinophilic conditions: eosinophilic asthma (4 replicate...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-65239 | biostudies-arrayexpress
TranscriptomicsComparison of coding RNA expression in steady-state and in response to IL33 and IL5 stimulation in bone marrow eosinophils from IL5-deficient and wild-type littermates
Aim of the experiment was to assess differences in expression of coding RNA between bone marrow eosinophils arising in IL-5 knock-out mice (C57BL/6-Il5tm1Kopf/J) or wild-type littermates and their response to cytokine stimulation. Bone marrow eosinophils were sorted by FACS submitted to RNA-seq imme...
ORGANISM(S): Mus musculus 
2021-12-17 | E-MTAB-10188 | biostudies-arrayexpress
TranscriptomicsComparison of coding RNA expression of blood eosinophils from mepolizumab- or omalizumab-treated severe asthmatic patients and from healthy controls
RNA-seq comparison of coding RNA expression in blood eosinophils from patients with severe allergic eosinophilic asthma treated with mepolizumab with those of healthy controls and matched severe asthmatic patients receiving omalizumab.
ORGANISM(S): Homo sapiens 
2021-12-17 | E-MTAB-10190 | biostudies-arrayexpress
ProteomicsTime-course Activation of Human Peripheral Blood Eosinophils by Cytokines
Activated eosinophils contribute to airway dysfunction and tissue remodeling in asthma, and thus are considered an important factor in asthma pathology. We report here comparative proteomic and phosphoproteomic changes upon activation of eosinophils using eight cytokines individually and in selected...
ORGANISM(S): Homo sapiens (Human) 
2017-12-19 | PXD004043 | Pride
Proteomics Asthma Mass spectrometry Activation Flow cytometry Cytokines Phosphoproteomics Eosinophils 
TranscriptomicsmiR-223 Bone Marrow Derived Eosinophils
Gene expression profiling of bone marrow derived eosinophils from miR-223 wildtype or miR-223 deficient mice
ORGANISM(S): Mus musculus 
2012-08-25 | E-MEXP-3350 | biostudies-arrayexpress
TranscriptomicsExpression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma
This SuperSeries is composed of the following subset Series: GSE15345: Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma 1 GSE15414: Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma 2...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-15429 | biostudies-arrayexpress
TranscriptomicsEosinophils scRNA-seq from healthy and asthmatic donors
scRNA-seq data from human eosinophils purified from blood samples. Samples include three healthy patients and three asthmatic donors.
ORGANISM(S): Homo sapiens 
2024-04-23 | E-MTAB-14010 | biostudies-arrayexpress
GenomicsEosinophils in Lung Allograft
Eosinophils in Lung Allograft
PRJNA925858 | ENA
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