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TranscriptomicsRNA-Seq profiling of single bovine oocyte transcript abundance and its modulation by cytoplasmic polyadenylation
Polyadenylated RNA from individual germinal vesicle and metaphase II ooyctes was amplified and processed for Illumina sequencing. Increases in polyadenylated transcript abundance were observed and are likely due to cytoplasmic polyadenylation. Transcriptomic analysis of GV and MII bovine oocytes.
ORGANISM(S): Bos taurus 
2015-07-08 | E-GEOD-61717 | biostudies-arrayexpress
TranscriptomicsExtensive alternative polyadenylation during zebrafish development
The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3' untranslated regions (3'UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling by sequencing (3P-Seq) to map poly(A) sites at eight developmental stages an...
ORGANISM(S): Danio rerio 
2012-06-17 | E-GEOD-37453 | biostudies-arrayexpress
TranscriptomicsCytoplasmic polyadenylation is a major regulator of mRNA fate during oogenesis and egg activation.
The GLD-2 class of poly(A) polymerases regulate the timing of translation of stored transcripts by elongating the poly(A) tails of target mRNAs in the cytoplasm. WISPY is a GLD-2 enzyme that acts in the Drosophila female germline and is required for the completion of the egg-to-embryo transition. Th...
ORGANISM(S): Drosophila melanogaster 
2016-05-18 | E-GEOD-81495 | biostudies-arrayexpress
GenomicsCpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis
Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis
PRJNA857656 | ENA
TranscriptomicsKnockdown of SR protein family in P19 cells and RNA-seq of cytoplasmic and whole cell polyA+ RNA
Our data suggest that all SR proteins contribute to mRNA export via NXF1. To identify endogenous export targets we depleted all seven SR proteins individually from P19 WT cells prepared cytoplasmic fractions. We sequenced the cytoplasmic fraction and as a control whole celll RNA from the identical s...
ORGANISM(S): Mus musculus 
2016-03-07 | E-GEOD-69733 | biostudies-arrayexpress
TranscriptomicsPaf1C plays novel subunit-specific roles in alternative cleavage and polyadenylation
The PAF complex (Paf1C) has been shown to regulate chromatin modifications, gene transcription, and PolII elongation. Here, we provide the first genome-wide analysis of chromatin occupancy by the entire PAF complex in mammalian cells. We show that Paf1C is recruited not only to promoters and gene bo...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-72574 | biostudies-arrayexpress
ProteomicsTENT5A mediated cytoplasmic polyadenylation in osteoblast supports proper bone formation.
The bone formation, osteogenesis, is a very complex process in which osteoblasts play a crucial role. The primary function of theses terminally differentiated mesenchymal stem cells is the secretion of fibrillary, dense, highly crosslinked type 1 collagen. Herein we show that the TENT5A gene, which...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD020346 | Pride
Collagen Mice Lc-ms/ms 
GenomicsAtaxin-2, Twenty-four and Dicer-2 are components of a non-canonical cytoplasmic polyadenylation complex
Ataxin-2, Twenty-four and Dicer-2 are components of a non-canonical cytoplasmic polyadenylation complex
PRJNA784931 | ENA
UnknownCytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development.
Not available
S-EPMC2661069 | biostudies-literature
UnknownDicer-2 promotes mRNA activation through cytoplasmic polyadenylation.
Not available
S-EPMC5855953 | biostudies-literature
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