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ProteomicsCompetitive Binding and Molecular Crowding Regulate the Cytoplasmic Interactome of Non-Viral Polymeric Gene Delivery Vectors
In contrast to the processes controlling the complexation, targeting and uptake of polycationic gene delivery vectors, the molecular mechanisms regulating their cytoplasmic dissociation remains poorly understood. Upon cytosolic entry, vectors become exposed to a complex, concentrated mixture of mole...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028512 | Pride
Gene delivery Rna delivery Polymer brush Proteomics Cytosolic interactome Polycationic vector Lc-ms/ms 
TranscriptomicsA host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
The innate immune system responds to unique molecular signatures that are widely conserved among microbes but that are not normally present in host cells. Compounds that stimulate innate immune pathways may be valuable in the design of novel adjuvants, vaccines, and other immunotherapeutics.The cyc...
ORGANISM(S): Mus musculus 
2009-07-21 | E-GEOD-16943 | biostudies-arrayexpress
ProteomicsDynamic Assembly of the Cytosolic Iron-Sulfur Cluster Biogenesis Machinery Requires Iron-Sulfur Cluster Incorporation of CIAO3
Cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway delivers Fe-S clusters to nuclear and cytosolic Fe-S proteins involved in essential cellular functions. This delivery process is regulated by availability of iron and oxygen, but it remains unclear how CIA components orchestrate the cluster...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-16 | MSV000088394 | MassIVE
ProteomicsIron-Regulated Assembly of the Cytosolic Iron-Sulfur Cluster Biogenesis Machinery
The cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway delivers Fe-S clusters to nuclear and cytosolic Fe-S proteins involved in essential cellular functions. Although the delivery process is regulated by the availability of iron and oxygen, it remains unclear how CIA components orchestrate...
ORGANISM(S): Homo Sapiens 
PXD033557 | panorama
UnknownFluoroalkylation promotes cytosolic peptide delivery.
Not available
S-EPMC7423368 | biostudies-literature
UnknownDirect Cytosolic Delivery of Proteins through Coengineering of Proteins and Polymeric Delivery Vehicles.
Not available
S-EPMC7392052 | biostudies-literature
UnknownSingle-cell quantification and dose-response of cytosolic siRNA delivery.
Not available
S-EPMC9968291 | biostudies-literature
UnknownEndosomolytic reducible polymeric electrolytes for cytosolic protein delivery.
Not available
S-EPMC3759265 | biostudies-literature
UnknownSupramolecular caging for cytosolic delivery of anionic probes.
Not available
S-EPMC7017865 | biostudies-literature
UnknownDirect Cytosolic Delivery of Proteins Using Lyophilized and Reconstituted Polymer-Protein Assemblies.
Not available
S-EPMC10587898 | biostudies-literature
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