Cytotoxic t lymphocyte

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Unknown (3004)
Transcriptomics (911)
Genomics (408)
Proteomics (83)
Metabolomics (36)
Models (16)
Other (14)
Genomic (6)
Clinical (5)
Multiomics (1)

Organisms

Homo sapiens (615)
Mus musculus (453)
Rattus norvegicus (26)
Bos taurus (14)
Macaca mulatta (5)
Gallus gallus (4)
Mus (3)
Phytophthora infestans (3)
Drosophila melanogaster (3)
Arabidopsis thaliana (3)
Mycobacterium tuberculosis (2)
Salmo salar (2)
Sus scrofa (2)
Ictalurus punctatus (2)
gut metagenome (1)
Papio cynocephalus (1)
Litomosoides sigmodontis (1)
Helianthus annuus (1)
Thermoplasma acidophilum DSM 1728 (1)
Mustela putorius furo (1)
Populus x canadensis (1)
Marmota monax (1)
Oryzias latipes (1)
Chlorocebus sabaeus (1)
Macaca fascicularis (1)
Schistosoma mansoni (1)
Zea mays (1)
Oryctolagus cuniculus (1)
Ovis aries (1)
Plasmodium falciparum (1)

Organisms

Mus musculus (90)
Homo sapiens (78)
Rattus norvegicus (2)
Ictalurus punctatus (1)
Danio rerio (1)
Gallus gallus (1)

Repository

biostudies-arrayexpress (829)
ENA (210)
geo (156)
EGA (143)
MetaboLights (36)
MassIVE (29)
pride (24)
jPOST (15)
BioModels (11)
dbGaP (6)
Cell Collective (5)
iProX (5)
GPMDB (3)
EVA (2)
PAXDB (1)

Tissue

T cell (11)
Cell culture (8)
Cytotoxic T-lymphocyte (6)
Spleen (3)
CD8-positive (2)
Epithelial cell (2)
Lung (2)
Lymph node (2)
Adrenal gland (1)
B-lymphocyte (1)
Blood cell (1)
Blood platelet (1)
Blood vessel endothelial cell (1)
Brain (1)
Cell suspension culture (1)
Colon (1)
Cytotoxic T cell (1)
Cytotoxic T-lymphocyte protein 4 (mouse) (1)
Esophagus (1)
Frontal lobe (1)
Gall bladder (1)
Gut (1)
Heart (1)
Helper T-lymphocyte (1)
Keratinocyte (1)
Kidney (1)
Liver (1)
Lymphocyte (1)
MEF cell (1)
Macrophage (1)

Disease

Colorectal Neoplasms (3)
Not Available (3)
Normal (2)
Melanoma (2)
XCGD (1)
Active ITP (1)
Cytomegalovirus seropositive (1)
Aggressive insulitis (1)
Large cell carcinoma (1)
Extranodal NK/T-Cell Lymphoma derived cell line (1)
Asthma (1)
Chronic infection with geohelminth ascaris lumbricoides (1)
Represent tolerant CD4+ T cells that have not been activated (1)
Lung large cell carcinoma (1)
Colonic Neoplasms (1)
Neoplasms (1)
Breast cancer (1)
Disease free (1)
Inflammation (1)
Lung adenocarcinoma (1)
T-cell large granular lymphocyte leukemia (1)

Technology Type

Mass Spectrometry (24)
Mass spectrometry (21)
Mass spectrometry assay (15)
Shotgun proteomics (9)
Bottom-up proteomics (8)
Data-dependent acquisition (5)
Affinity purification coupled with mass spectrometry proteomics (3)
Data-independent acquisition (3)
Illumina Oncoscan Array (1)
ILLUMINA, Illumina HiSeq 2500, NextSeq 500, Nanostring (1)
NextSeq 500, ILLUMINA (1)
Illumina HiSeq 2500, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 2500 (1)
NMR spectroscopy assay (1)
Gel-based experiment (1)
HDMSE (1)
Top-down proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (34)
Illumina HiSeq 4000 (13)
Illumina HiSeq 2500 (12)
NextSeq 500 (12)
Illumina MiSeq (4)
Illumina NovaSeq X (3)
NextSeq 550 (3)
Illumina HiSeq 2000 (3)
BAS-5000 [FUJIFILM] (2)
DNBSEQ-T7 (2)
BGISEQ-500 (2)
Illumina HiSeq 1500 (2)
NanoString nCounter (1)
10X Genomics Single Cell, V3.1 (1)
RStudio and R with illuminaio, sva and BioMart packages (1)
HumanHT-12 V4 beadarray (1)
Illumina TotalPre-96 RNA Amp kit (1)
NucleoSpin RNA kit, NanoDrop ND-1000 and Agilent 2100 bioanalyzer (1)
Dynabeads CD8+ isolation kit (1)
Novogene automated library prep system (1)
Qiagen RNA extraction kit (1)
Local workstation (1)
Chromium Single Cell 5' Library & Gel Bead Kit v2 (1)
FLOQSwab (Copan) (1)
DNA 7500 Bioanalyzer Chips (1)
MoFlo XDP (Beckman Coulter) or a FACSAria II (Becton Dickinson) (1)
Fluidigm C1 autoprep system (1)
BD FACSAria III (1)
Centrifuge (1)
Gene Titan (1)

Publication Date

2015 (108)
2013 (100)
2012 (98)
2014 (93)
2010 (86)
2024 (63)
2025 (63)
2016 (60)
2011 (59)
2008 (54)
2026 (53)
2009 (42)
2022 (39)
2023 (38)
2020 (30)
2021 (29)
2018 (27)
2007 (23)
2019 (20)
2017 (9)
2006 (6)
2005 (5)
2004 (2)
2027 (1)

UNIPROT ID/AC

Q15116 (1)
P16410 (1)
P01137 (1)
1433B_MOUSE (1)
1433E_MOUSE (1)
1433F_MOUSE (1)
1433G_MOUSE (1)
1433S_MOUSE (1)
1433T_MOUSE (1)
1433Z_MOUSE (1)
2A5A_MOUSE (1)
2A5E_MOUSE (1)
2A5G_MOUSE (1)
2AAA_MOUSE (1)
2AAB_MOUSE (1)
2ABA_MOUSE (1)
2ABD_MOUSE (1)
3BP1_MOUSE (1)
3BP2_MOUSE (1)
3BP5L_MOUSE (1)
3HAO_MOUSE (1)
3HIDH_MOUSE (1)
3MG_MOUSE (1)
41_MOUSE (1)
4EBP1_MOUSE (1)
4EBP2_MOUSE (1)
4ET_MOUSE (1)
4F2_MOUSE (1)
5NT3A_MOUSE (1)
5NT3B_MOUSE (1)

CHEBI ID

CHEBI:15354 (7)
CHEBI:73004 (6)
CHEBI:18257 (6)
CHEBI:16566 (6)
CHEBI:16196 (6)
CHEBI:16737 (6)
CHEBI:17895 (6)
CHEBI:17596 (6)
CHEBI:15756 (6)
CHEBI:17368 (6)
CHEBI:72736 (5)
CHEBI:17033 (5)
CHEBI:74340 (5)
CHEBI:28238 (5)
CHEBI:16113 (5)
CHEBI:18049 (5)
CHEBI:18132 (5)
CHEBI:16040 (5)
CHEBI:64489 (5)
CHEBI:72665 (5)
CHEBI:16610 (5)
CHEBI:16235 (5)
CHEBI:17568 (5)
CHEBI:17203 (5)
CHEBI:15891 (5)
CHEBI:16359 (5)
CHEBI:73722 (5)
CHEBI:48131 (5)
CHEBI:17385 (5)
CHEBI:59132 (1)

Metabolite Name

L-Proline (10)
L-Tyrosine (9)
L-Tryptophan (7)
Creatine (7)
Uracil (6)
L-Lysine (6)
Phytosphingosine (6)
L-Histidine (6)
Choline (6)
Sphinganine (6)
Spermidine (6)
Guanine (6)
L-Valine (6)
Inosine (6)
PE(16:0/0:0) (5)
Phenylacetaldehyde (5)
L-Alanine (5)
Thymine (5)
Niacinamide (5)
L-Glutamic acid (5)
Palmitic acid (5)
Oleic acid (5)
Xanthine (5)
Thymidine (5)
L-Phenylalanine (5)
Arginylproline (4)
Hydroxyurea (4)
Dicyclohexylamine (4)
Maltol (4)
D-Ornithine (4)

First Public Date

2026 (33)
2025 (30)
2024 (21)
2023 (21)
2020 (20)
2022 (18)
2018 (14)
2014 (13)
2021 (11)
2019 (11)
2017 (7)
2015 (7)
2016 (3)
2013 (1)

Modelling Approach

Ordinary differential equation model (9)

Study status

Recruiting (2)
Completed (2)
Active, not recruiting (1)

Lab affiliation

Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421 Homburg, Germany (2)
Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, CB2 0XY, UK (1)
Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK (1)
Centre for Proteomic Research B85, Life Sciences Building University of Southampton University Road Highfield Southampton, Hants. SO17 1BJ United Kingdom (1)
Departement of Cell Biology, Harvard Medical School (1)
Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA. (1)
Department of Diagnostic Sciences, Ghent University, Ghent, Belgium. Cancer Research Institute Ghent (CRIG), Ghent, Belgium. (1)
Department of Medical Informatics and Statistics, BK21 Project, Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea. (1)
Discovery Proteomics Facility, University of Oxford (1)
Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, UK (1)
Icahn School of Medicine at Mount Sinai (1)
Institut für Experimentelle Medizin (IEM) Arbeitsgruppe Systematische Proteomforschung Christian-Albrechts-Universität zu Kiel Niemannsweg 11 24105 Kiel, Germany (1)
Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China. (1)
Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, China (1)
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 USA (1)
Molecular Cell Biology Lab, Dept. Molecular Hematology Sanquin Research and Landsteiner Laboratory Academic Medical Center at the University of Amsterdam Plesmanlaan 125, 1066CX Amsterdam, the Netherlands Phone: +31205123042 E-mail: j.vanbuul@sanquin.nl (1)
School of Life Sciences, University of Dundee, Dundee (1)
School of Life Sciences, University of Dundee, Dundee, UK(lab head) (1)
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China (lab head) (1)
The University of Texas, MD Anderson Cancer Center, Department of Melanoma Med Oncology, Houston, TX 77045 (1)
Thoracic and GI Malignancies Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892 (1)
Translational Oncology Research Center, Vrije Universiteit Brussel (VUB), Brussels, Belgium (1)
University of California San Diego (1)

Keyword

Immunotherapy (3)
Oncolytic Vaccinia Virus (1)
Tumor Cell Death (1)
Viral Therapy (1)
Anti-Tumor Immunity (1)
Anti-CTLA-4 (1)
Monotherapy (1)
Second line (1)
Open-label (1)
Anti-PD-1 (1)
Tremelimumab (1)
Dose Escalation (1)
PD-1 (1)
CTLA-4 (1)
Combination Therapy (1)
Durvalumab (1)
Aflibercept (1)
Panitumumab (1)
Avelumab (1)
Bevacizumab (1)
Cetuximab (1)

IsPrivate

False (11)

Submitter Keywords

Immuno-oncology (5)

Modification

4-dinitrophenyl modified residue (1)

Study type

Transcription profiling by array (579)
RNA-seq of coding RNA (102)
ChIP-seq (34)
RNA-seq of coding RNA from single cells (25)
Transcription profiling by RT-PCR (12)
Methylation profiling by array (12)
Proteomic profiling by array (9)
RNA-seq of non coding RNA (8)
RNA-seq of total RNA (6)
Interventional (5)
Comparative genomic hybridization by array (4)
MicroRNA profiling by array (4)
DNA-seq (4)
Unknown experiment type (3)
Human - One-color microarray (3)
Methylation profiling by high throughput sequencing (3)
Animal - One-color microarray (2)
ChIP-chip by tiling array (2)
Human - High-throughput sequencing (2)
Spatial transcriptomics by high-throughput sequencing (2)
ATAC-seq (2)
Other (2)
RNA-seq of non coding RNA from single cells (1)
Cell line - Two-color microarray (1)
Human - Single-cell sequencing (1)
High-throughput sequencing (1)
Animal - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
RNAi profiling by array (1)
Genotyping by array (1)

Release Date

2022 (375)
2021 (320)
2023 (311)
2025 (298)
2020 (270)
2024 (241)
2015 (222)
2014 (184)
2019 (179)
2018 (179)
2016 (177)
2013 (161)
2017 (152)
2012 (152)
2010 (132)
2011 (100)
2008 (85)
2009 (77)
2007 (51)
2026 (41)
2006 (28)
2005 (28)
2004 (16)
1999 (13)
2003 (10)
2002 (8)
2000 (7)
1998 (7)
2001 (6)
1997 (2)

Location

United States (3)
France (2)

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Nanoinducers-mediated Mitochondria-Selective Degradation Enhance T Cell Immunotherapy Against Multiple Cancers

Cancer immunotherapy utilizing cytotoxic T lymphocytes (CTLs) has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondria content and their resis...

2025-03-13 | MTBLS12284 | MetaboLights

M.musculus - T cell, SC (Hukelmannetal,natimmunol2016)

abundance based on Spectral counting, Interaction consistency score: 16.2, Coverage: 30

ORGANISM(S): 10090

2016-00-00 | 190918057 | PAXDB

Comparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells

Introduction

Chronic inflammation is a hallmark of chronic wounds and inflammatory skin diseases. Due to a hyperactive and prolonged inflammation triggered by proinflammatory immune cells, transitioning to the repair and healing phase is halted. T cells may exacerbate the proinflammatory mil...

2025-07-09 | MTBLS9800 | MetaboLights

A microRNA-directed program of cytotoxic CD8+ T cell differentiation

Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes (CTLs). Here we show that inflammatory signals regulate Dicer expression in CTL, and that deletion or depletion of Dicer in mouse or human activated CD8+ T cells causes upregulation of perforin, granzyme an...

ORGANISM(S): Mus musculus

2013-12-02 | E-GEOD-51393 | biostudies-arrayexpress

Expression data from P14 TCR cytotoxic T cells overexpressing HDAC7 phosphorylation deficient mutant

The present study reports an unbiased analysis of the cytotoxic T cell serine-threonine phosphoproteome using high resolution mass spectrometry. Approximately 2,000 phosphorylations were identified in CTLs of which approximately 450 were controlled by TCR signaling. A significantly overrepresented g...

ORGANISM(S): Mus musculus

2011-03-13 | E-GEOD-27092 | biostudies-arrayexpress

Transcription profiling of mouse cytotoxic T lymphocyte cell line CTLL-2 treated with interleukin-2

The cytokine IL-2 determines T cell fate by controlling T cell proliferation and differentiation, but the expression files of IL-2 regulated genes are not defined; Using Affymetrix mouse genome array and mouse T cell line CTLL-2, we analyzed the expression profiles of IL-2 regulated genes over 10 ti...

ORGANISM(S): Mus musculus

2008-11-22 | E-GEOD-6085 | biostudies-arrayexpress

Fuzheng Jiedu Xiaoji Formula Enhances Anti-PD-1 Therapy for Hepatocellular Carcinoma by Inhibiting Regulatory T Cell Lipotoxicity

Background: The objective response rate of anti-programmed death receptor 1 (PD-1) immunotherapy in hepatocellular carcinoma (HCC) remains limited. The tumor immunosuppressive microenvironment mediated by regulatory T cells (Tregs) is a key bottleneck. The traditional Chinese medicine (TCM) compo...

2025-12-05 | MTBLS13458 | MetaboLights

The impact of hypoxia on the cytotoxic T lymphocyte proteome

Metabolic and nutrient-sensing pathways play an important role in controlling the efficacy of effector T cells. Oxygen is a critical regulator of cellular metabolism. However, during immune responses T cells must function in oxygen-deficient, or hypoxic, environments. Here, we used high resolution m...

ORGANISM(S): Mus musculus (Mouse)

2021-10-20 | PXD026223 | Pride

Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks.

Data from ProteomeXchange, PXD ID: PXD001076. Experiment: JG-N2, file: JG-N2-12.mzml. Published as part of Mol Cell Proteomics. 2014 Sep 29 . From the Abstract: {{i}} ... We used Stable Isotope of Amino acids in Culture (SILAC) combined with phosphopeptide enrichment and quantitative mass-spectrome...

ORGANISM(S): Mus_musculus_viruses, Mouse

GPM32320004050 | GPMDB

Resource Reanalysis

RNA-seq of murine cytotoxic T lymphocytes in response to myosin IIA inhibition using para-nitroblebbistatin

This project explores the effects of inhibiting myosin IIA using para-nitroblebbistatin (pNB) on effector cytotoxic T lymphocyte (CTL) activation. Effector CTLs were differentiated from OTI TCR transgenic mice for 7 days in vitro, then stimulated (or not stimulated) with anti-CD3 for 1 hour, treated...

ORGANISM(S): Mus musculus

2025-09-27 | E-MTAB-14579 | biostudies-arrayexpress

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