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ProteomicsQuantification of ATIs in Wheat by LC-MS/MS – LFQ DIA QTOF
A selection of ATIs was silenced in the common wheat cultivar Bobwhite and durum wheat cultivar Svevo by RNAi and gene editing, respectively, in order to reduce the amounts of ATIs. The controls and silenced lines were analyzed after digestion to peptides by LC-MS/MS with different approaches to eva...
ORGANISM(S): Triticum aestivum (Wheat) 
2022-10-13 | PXD034509 | Pride
Amylase/trypsin inhibitor  wheat  crsipr-cas9  rnai 
ProteomicsINPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH
In this study, we describe new patients suffering from INPP5K mutations and hereby expand the mutational and clinical spectrum of the underlying disease. Pathogenicity of a new INPP5K missense mutation has been functionally confirmed. In addition, we systematically addressed the need to identify com...
ORGANISM(S): Homo sapiens (Human) 
2021-04-06 | PXD009297 | Pride
L-serine Inpp5k Bip Phgdh Sil1 
ProteomicsINPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH
In this study, we describe new patients suffering from INPP5K mutations and hereby expand the mutational and clinical spectrum of the underlying disease. Pathogenicity of a new INPP5K missense mutation has been functionally confirmed. In addition, we systematically addressed the need to identify com...
ORGANISM(S): Homo sapiens (Human) 
2021-04-06 | PXD009272 | Pride
L-serine Inpp5k Bip Phgdh Sil1 
UnknownDysregulated balance of D- and L-amino acids modulating glutamatergic neurotransmission in severe spinal muscular atrophy.
Not available
S-EPMC11980034 | biostudies-literature
UnknownDysregulated balance of D- and L-amino acids modulating glutamatergic neurotransmission in severe spinal muscular atrophy.
Not available
S-EPMC11526884 | biostudies-literature
UnknownPerformance of 18F-DCFPyL PET/CT in Primary Prostate Cancer Diagnosis, Gleason Grading and D'Amico Classification: A Radiomics-Based Study.
Not available
S-EPMC10781655 | biostudies-literature
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
ProteomicsQuantification of ATIs in Wheat by LC-MS/MS – LFQ IonTrap
A selection of ATIs was silenced in the common wheat cultivar Bobwhite and durum wheat cultivar Svevo by RNAi and gene editing, respectively, in order to reduce the amounts of ATIs. The controls and silenced lines were analyzed after digestion to peptides by LC-MS/MS with different approaches to eva...
ORGANISM(S): Triticum aestivum (Wheat) 
2022-10-14 | PXD034769 | Pride
Amylase/trypsin inhibitor  wheat  crsipr-cas9  rnai 
UnknownNo Evidence for Light-Induced Embolism Repair in Cut Stems of Drought-Resistant Mediterranean Species under Soaking.
Not available
S-EPMC8840644 | biostudies-literature
UnknownSynthesis and accumulation of amylase-trypsin inhibitors and changes in carbohydrate profile during grain development of bread wheat (Triticum aestivum L.).
Not available
S-EPMC7905651 | biostudies-literature
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