Sort   by:  
 Page size 
ProteomicsOncometabolism Drives Autophagy Activation in Skeletal Muscle
Metabolic rewiring is a well-established feature of muscle cells and a hallmark of cancer. In isocitrate dehydrogenase 1 and 2 mutant tumors, increased production of the oncometabolite D-2-hydroxyglutarate (D2-HG) is associated with myopathy. The connection between metabolic changes and proteomic re...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD022137 | Pride
Autophagy Mouse Cancer Cachexia D2-hg Skeletal muscle 
UnknownAutophagic signaling promotes systems-wide remodeling in skeletal muscle upon oncometabolic stress by D2-HG.
Not available
S-EPMC11278897 | biostudies-literature
TranscriptomicsOncometabolism Drives Autophagy Activation in Skeletal Muscle
We hypothesize that the oncometabolite D2-HG activates autophagy in skeletal muscle.
ORGANISM(S): Mus musculus 
2025-04-04 | GSE159772 | GEO
GenomicsOncometabolism Drives Autophagy Activation in Skeletal Muscle
Oncometabolism Drives Autophagy Activation in Skeletal Muscle
PRJNA670469 | ENA
TranscriptomicsD-2-Hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) have been discovered in several cancer types and cause the neurometabolic syndrome D2-Hydroxyglutaric aciduria (D2HGA). The mutant enzymes exhibit neomorphic activity resulting in production of D2- hydroxyglutaric acid (D-2HG). To study the path...
ORGANISM(S): Mus musculus 
2014-03-01 | GSE54838 | GEO
UnknownD2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2.
Not available
S-EPMC4515030 | biostudies-literature
UnknownOncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart.
Not available
S-EPMC5027422 | biostudies-literature
UnknownMutant IDH in Gliomas: Role in Cancer and Treatment Options.
Not available
S-EPMC10252079 | biostudies-literature
TranscriptomicsD-2-Hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) have been discovered in several cancer types and cause the neurometabolic syndrome D2-Hydroxyglutaric aciduria (D2HGA). The mutant enzymes exhibit neomorphic activity resulting in production of D2- hydroxyglutaric acid (D-2HG). To study the pat...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-54838 | biostudies-arrayexpress
UnknownCharacterization of Modified Natural Minerals and Rocks for Possible Adsorption and Catalytic Use.
Not available
S-EPMC7663305 | biostudies-literature
Sort   by:  
 Page size