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ProteomicsTGF-Beta-induced Dact1 Biomolecular Condensates Repress Wnt Signaling via Multivalent Protein-Protein Interactions
Isolation and characterization of Dact1 biomolecular condensates with and without Wnt stimulation in breast cancer bone metastatic cells.
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD019271 | Pride
Beta catenin Wnt Dact1 Frodo Dapper Tgf-ß Biomolecular condensates Bone metastisis Phase separation 
Genomicsdact1/2 modifies noncanonical Wnt signaling and calpain 8 expression to regulate convergent extension and craniofacial development
dact1/2 modifies noncanonical Wnt signaling and calpain 8 expression to regulate convergent extension and craniofacial development
PRJNA1003061 | ENA
UnknownOncogenic function of DACT1 in colon cancer through the regulation of β-catenin.
Not available
S-EPMC3309901 | biostudies-literature
Transcriptomicsdact1/2 modifies noncanonical Wnt signaling and calpain 8 expression to regulate convergent extension and craniofacial development
Wnt signaling plays a fundamental role in the initial patterning and development of the embryo, including in the regulation of convergent extension during gastrulation and the establishment of the dorsal axis. Further, Wnt signaling is a crucial regulator of craniofacial morphogenesis. The relations...
ORGANISM(S): Danio rerio 
2024-09-04 | GSE240264 | GEO
OtherM6A Demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression [MeRIP-seq]
Despite advances in clinical diagnosis and treatment, the prognosis of patients with osteosarcoma (OS) remains poor, and the treatment efficacy has plateaued. Therefore, it is important to identify new therapeutic targets for OS. N6-methyladenosine (m6A) modification has been reported to participate...
ORGANISM(S): Homo sapiens 
2024-11-30 | GSE189877 | GEO
TranscriptomicsM6A Demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression [RNA-seq]
Despite advances in clinical diagnosis and treatment, the prognosis of patients with osteosarcoma (OS) remains poor, and the treatment efficacy has plateaued. Therefore, it is important to identify new therapeutic targets for OS. N6-methyladenosine (m6A) modification has been reported to participate...
ORGANISM(S): Homo sapiens 
2024-11-30 | GSE189878 | GEO
GenomicsM6A Demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression [MeRIP-seq]
M6A Demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression [MeRIP-seq]
PRJNA784948 | ENA
GenomicsM6A Demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression [RNA-seq]
M6A Demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression [RNA-seq]
PRJNA784947 | ENA
UnknownHeterozygous Pathogenic Variant in DACT1 Causes an Autosomal-Dominant Syndrome with Features Overlapping Townes-Brocks Syndrome.
Not available
S-EPMC5390682 | biostudies-literature
UnknownTGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis.
Not available
S-EPMC7970447 | biostudies-literature
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