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ProteomicsIntracellular Iron Accumulation Facilitates Mycobacterial Infection in Old Mouse Macrophages
Aging has a significant impact on the immune system, leading to a gradual decline in immune function and changes in the body's ability to respond to bacterial infections. Non-tuberculous mycobacteria (NTM), also known as atypical mycobacteria or environmental mycobacteria, are commonly found in soil...
ORGANISM(S): Mycobacterium avium Mus musculus (Mouse) Mycobacterium tuberculosis 
2024-05-24 | PXD045821 | Pride
Macrophages Iron Mycobacterium Aging 
UnknownIntracellular iron accumulation facilitates mycobacterial infection in old mouse macrophages.
Not available
S-EPMC10828278 | biostudies-literature
UnknownBicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades.
Not available
S-EPMC6699834 | biostudies-literature
UnknownTargeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice.
Not available
S-EPMC3734182 | biostudies-literature
UnknownIrreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death.
Not available
S-EPMC7083616 | biostudies-literature
Unknown12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.
Not available
S-EPMC2936618 | biostudies-literature
ProteomicsRedox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation
PTPN22, a modifier of T cell receptor signaling, and reactive oxygen species are major players in the regulation of chronic autoimmune diseases. As with all protein tyrosine phosphatases the activity of PTPN22 is redox regulated, but if or how such regulation can modulate inflammatory pathways in vi...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-23 | PXD025319 | Pride
Autoimmunity Ptpn22 Reactive oxygen species Lymphocyte signaling 
UnknownRedox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation.
Not available
S-EPMC9119677 | biostudies-literature
UnknownControl of protein function through oxidation and reduction of persulfidated states.
Not available
S-EPMC6938701 | biostudies-literature
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