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MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
ProteomicsAnti-Toxoplasma gondii effect of vorinostat in vitro and in vivo
Toxoplasma gondii is an important pathogenic protozoon that infects up to one-third of the world's population. In immunocompetent individuals, the infection generally is asymptomatic. However, in immunocompromised patients, the infection can lead to severe and fatal complications. This is due to the...
ORGANISM(S): Toxoplasma Gondii Rh-88 
PXD053997 |
UnknownComputational design of conformation-biasing mutations to alter protein functions.
Not available
S-EPMC12157495 | biostudies-literature
TranscriptomicsIdentification of the gene expression in IPF lung fibroblasts after demethylation
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Although the pathogenesis is poorly understood, evidence suggests that genetic and epigenetic alterations, such as DNA methylation, may play a key role. We used microarrays to see the gene expression in IPF fibroblasts after demethyl...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-69764 | biostudies-arrayexpress
UnknownFamine Exposure during Early Life and Risk of Cancer in Adulthood: A Systematic Review and Meta-Analysis.
Not available
S-EPMC12929998 | biostudies-literature
ProteomicsTumor suppressor TAp73 is required to maintain pluripotency of cancer stem cells
Cancer stem cells (CSCs) are resistant to conventional chemotherapy and are hence responsible for cancer relapse. Pluripotency is a characteristic of CSCs which allows them to rapidly proliferate while maintaining the ability to differentiate into various lineages. We found that TAp73, but not its h...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD005407 | Pride
Stem cells P73 
ProteomicsMice liver and urine LC-MS data
Mouse livers were analyzed by lipidomics and urine by metabolomics.An Agilent Ultra-Performance Liquid Chromatography/Electrospray Ion Quadrupole Time-of-Flight-Mass Spectrometer (UPLC-ESI-QTOFMS) (Agilent, Santa Clara, CA) was utilized for lipid and other metabolites proofing in this work.
ORGANISM(S): Mus musculus (Mouse) 
2023-06-07 | PXD041465 | Pride
Lc-ms Liver Mice Urine 
UnknownPrinted High-Entropy Prussian Blue Analogs for Advanced Non-Volatile Memristive Devices.
Not available
S-EPMC11854872 | biostudies-literature
MetabolomicsGut microbiota ameliorates hepatic fibrosis through modulating intestinal bile acid metabolism and hepatocyte pyroptosis (Hepatic fibrosis serum+feces)

Parabacteroides distasonis (P. distasonis) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P. distasonis is decreased in patients with hepatic fibrosis, and that administration of P. dista...

2023-03-17 | MTBLS6728 | MetaboLights
MetabolomicsGut microbiota ameliorates hepatic fibrosis through modulating intestinal bile acid metabolism and hepatocyte pyroptosis (Hepatic fibrosis serum)

Hepatic fibrosis decreased feces bile acid level. Hepatic fibrosis increased serum bile acid. This result showed that hepatic fibrosis inhibited the excretion of bile acid in clinical patients. This result provided phenotype for hepatic fibrosis patients. Bile acid was important indexes for liver...

2023-03-17 | MTBLS6732 | MetaboLights
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