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MetabolomicsOsh2 mediates Candida resistance to miltefosine by regulating zymosterol transport
Miltefosine has been identified for its antifungal properties, yet the mechanisms underlying its action and the development of resistance remain unclear. In this study, we induced drug resistance in various Candida species through concentration gradient exposure, successfully obtaining a miltefosine...
2025-07-03 | MTBLS12270 | MetaboLights
MetabolomicsMulti-omics reveals the protective mechanisms of Gastrodia elata ethyl acetate extract in vascular dementia

Objective: This study aimed to investigate the ameliorative effect of the ethyl acetate extract of Gastrodia elata (EEGE) on vascular dementia (VD) and its underlying mechanisms. 

Methods: A VD rat model was established using the two-vessel occlusion method, while an in vitro cerebral ...

2026-01-15 | MTBLS13695 | MetaboLights
Proteomics2022-0222-SK cell line infected by ZIKV（MR766,PRVABC.59)-1044
In this project, mass spectrometer Q-Exactive HF X was used. Total number of 43898 spectra were obtained from the sample group SK_mock. After identification by search engine, 6733 spectra were matched, 1094 proteins and 5074 peptides were identified.Total number of 46943 spectra were obtained from t...
ORGANISM(S): Homo Sapiens 
2024-03-25 | PXD050964 |
ProteomicsTemporal proteomics characterization of COVID-19 patient sera
We enrolled 37 SARS-CoV-2 positive patients including 17 short course (SC) COVID-19 patients (twice viral RNA detection negative over 24 hrs) and 20 COVID-19 long course (LC) COVID-19 patients. We also included 35 SARS-CoV-2 negative patients as control group. We collected 224 inactive serum samples...
ORGANISM(S): Homo Sapiens 
2022-07-26 | PXD035471 |
ProteomicsA Recombinant Vaccine Targeting Receptor-binding Domain of SARS-CoV-2 Spike Protein Induces Protective Immunity in Mice and Non-human Primates
The novel Coronavirus SARS-CoV-2 causes a respiratory illness called COVID-19 leading to a pandemic. An effective preventive vaccine against this virus is urgently needed.
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2020-07-30 | PXD020653 |
ProteomicsIdentification of antiviral RNAi regulators, ILF3/DHX9, recruit at ZIKV stem loop B to protect against ZIKV induced microcephaly
The stained gel bands are washed three times with ddH2O, followed by the addition of 150μL of destaining solution to remove the stain. After four rounds of water washing, the gel bands are washed twice with 300μL each of 25mM ammonium bicarbonate, 50% acetonitrile, and 100% acetonitrile, respectivel...
ORGANISM(S): Homo Sapiens 
2024-08-14 | PXD054904 |
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