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TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Mus musculus 
2015-10-26 | E-GEOD-67847 | biostudies-arrayexpress
GenomicsTissue-specific regulation of chromatin insulator function
Chromatin insulators organize the genome into distinct transcriptional domains and contribute to cell type-specific chromatin organization. However, factors regulating tissue-specific insulator function have not yet been discovered. Here we identify the RNA recognition motif-containing protein, Shep...
ORGANISM(S): Drosophila melanogaster 
2012-11-30 | E-GEOD-40797 | biostudies-arrayexpress
MetabolomicsExtracts from sweet sorghum (Sorghum bicolor), a feedstock for biorefining, suppressed proliferation and elevated apoptosis in human colon cancer stem cells via suppression of Wnt/beta-catenin signaling pathway
In colorectal cancer, p53 is commonly inactivated, associated with chemo-resistance, and marks the transition from non-invasive to invasive disease. Cancers, including colorectal cancer, are thought to be diseases of aberrant stem cell populations, as stem cells are able to self-renew, making them l...
2014-05-01 | MTBLS69 | MetaboLights
TranscriptomicsSu(Hw) and Shep RIP-seq in Kc and BG3 cell lines
Su(Hw) and Shep RIP-seq in Kc and BG3 cell lines RIP-seq with multiple antibodies to two proteins in two Drosophila cell lines, at least 2 replicates for each IP and input
ORGANISM(S): Drosophila melanogaster 
2014-07-29 | E-GEOD-55894 | biostudies-arrayexpress
UnknownSocioeconomically Disadvantaged Groups May Have Underused The Emergency Department For Nonavoidable Visits, 2018-22.
Not available
S-EPMC12236063 | biostudies-literature
TranscriptomicsGenome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila
Chromatin insulators are functionally conserved DNA-protein complexes that are situated throughout the genome and organize independent transcriptional domains.  Previous work implicated RNA as an important cofactor in chromatin insulator activity, although the mechanisms by which RNA affects insulat...
ORGANISM(S): Drosophila melanogaster 
2013-01-29 | E-GEOD-41950 | biostudies-arrayexpress
MetabolomicsNicotinamide Riboside is Uniquely Bioavailable in People and Mice
Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we conducted experiments to determine the time and dose-dependent effects of NR on blood, liver and heart NAD+ metabolism in people and mice. We report that human blood cell NAD+ can rise as much as 2.7-fold with a single d...
2016-09-09 | MTBLS368 | MetaboLights
UnknownLong-term organic carbon preservation enhanced by iron and manganese.
Not available
S-EPMC10499600 | biostudies-literature
TranscriptomicsComparative genomic hybridization of 25 Coxiella burnetii isolates relative to the Nine Mile (RSA493) reference isolate
Analysis of genetic diversity of 25 Coxiella burnetii isolates with relative to the Nine Mile (RSA493) reference isolate.
ORGANISM(S): Coxiella burnetii 
2006-10-30 | E-TABM-35 | biostudies-arrayexpress
TranscriptomicsGenomic analyses of Loc1, Puf6, and Khd1 binding patterns and transcriptional effects
We performed ChIP-chip of Loc1, Puf6, and Khd1 in order to determine the genetic loci they bind. We repeated these experiments with lighter fixation in the presence and absence of RNase to determine whether these associations are via DNA or RNA (analysis shows that they associate with the loci via ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-01 | E-GEOD-34245 | biostudies-arrayexpress
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