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GenomicsGenome-wide analysis of histone eviction by FAIRE-Seq
A major class of chemotherapeutics targets topoisomerase II for DNA double-strand breaks and cancer cell elimination. We compare four members of this class?the anthracyclines doxorubicin, daunorubicin and aclarubicin that does not induce DNA breaks?and a different compound, etoposide. We define a no...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-33632 | biostudies-arrayexpress
ProteomicsFrom incision to excision: active DNA damage eviction by HLTF stimulates repair
Nucleotide excision repair (NER) counteracts the onset of cancer and aging by removing helix-distorting DNA lesions via a ‘cut-and-patch’-type reaction. The regulatory mechanisms that drive NER through its successive damage recognition, verification, incision and gap restoration reaction steps remai...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD031243 | Pride
Uv damage response Hltf Repair synthesis Damage eviction Dna damage Tfiih Genome stability Post-replication repair Nucleotide excision repair 
GenomicsEpigenetic changes due to histone eviction induced by anthracycline doxorubicin and aclarubicin
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not i...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-33633 | biostudies-arrayexpress
TranscriptomicsTissue selective effects of topoisomerase II inhibitors in vivo
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. In vitro experiments showed that doxorubicin can induce histone eviction as well as DNA damage, while etoposide can only induce DNA damage. Here, we compare the tran...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-33626 | biostudies-arrayexpress
GenomicsGenome-wide analysis of histone eviction by FAIRE-Seq
Genome-wide analysis of histone eviction by FAIRE-Seq
PRJNA154327 | ENA
TranscriptomicsTopoisomerase II inhibitors and histone eviction
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-33634 | biostudies-arrayexpress
UnknownActive DNA damage eviction by HLTF stimulates nucleotide excision repair.
Not available
S-EPMC9473497 | biostudies-literature
GenomicsGenome-wide analysis of histone eviction by FAIRE-Seq
A major class of chemotherapeutics targets topoisomerase II for DNA double-strand breaks and cancer cell elimination. We compare four members of this class?the anthracyclines doxorubicin, daunorubicin and aclarubicin that does not induce DNA breaks?and a different compound, etoposide. We define a no...
ORGANISM(S): Mus musculus Homo sapiens 
2013-06-04 | GSE33632 | GEO
UnknownNo overt nucleosome eviction at deprotected telomeres.
Not available
S-EPMC2546919 | biostudies-literature
TranscriptomicsDistinct effects of topoisomerase II inhibitors on tumor cell lines (part 1)
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not i...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-33624 | biostudies-arrayexpress
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