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TranscriptomicsDepletion of beta1 integrins in triple negative breast cancer cells causes extensive alterations in gene expression profiles
Interactions with the extracellular matrix (ECM) through integrin adhesion receptors provide cancer cells with physical and chemical cues that act in concert with growth factors to support survival and proliferation. Preclinical studies testing beta1 integrin antagonists in (breast) cancer models h...
ORGANISM(S): Mus musculus 
2014-02-11 | E-MTAB-2185 | biostudies-arrayexpress
TranscriptomicsTempO-Seq of human breast cancer MCF-7 and HCC1143 cell lines under acute normoxia and hypoxia
Comparison of luminal and basal breast cancer cells under acute normoxia and hypoxia. Cells were plated in 96-well plates and incubated 24 hrs under normoxia or hypoxia after which the wells were washed once with cold PBS and lysed using TempO-Seq lysis buffer for 15 min at room temperature. Samples...
ORGANISM(S): Homo sapiens 
2023-06-01 | E-MTAB-12234 | biostudies-arrayexpress
TranscriptomicsTempO-Seq of human breast cancer MCF-7 and HCC1143 cell lines under chronic normoxia and hypoxia
Comparison of luminal and basal breast cancer cells under chronic normoxia and hypoxia. Cells were plated in 96-well plates and incubated 5 days under normoxia or hypoxia after which the wells were washed once with cold PBS and lysed using TempO-Seq lysis buffer for 15 min at room temperature. Sampl...
ORGANISM(S): Homo sapiens 
2023-06-01 | E-MTAB-12233 | biostudies-arrayexpress
MetabolomicsNormalization strategies for lipidome data in cell line panels & Distinct lipidomic profiles in breast cancer cell lines relate to proliferation and EMT phenotypes

Sample collection can significantly affect measurements of relative lipid concentrations in cell line panels, hiding intrinsic biological properties of interest between cell lines. Most quality control steps in lipidomic data analysis focus on controlling technical variation. Correcting for the t...

2025-08-07 | MTBLS9493 | MetaboLights
TranscriptomicsGene expression data from precision cut human liver slices treated to diclofenac
Drug-induced liver injury (DILI) is an important clinical problem. Here we used a genomics approach to establish the critical drug-induced toxicity pathways that act in synergy with the pro-inflammatory cytokine tumor necrosis factor (TNF) to cause cell death of liver HepG2 cells. Transcriptomics o...
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-54255 | biostudies-arrayexpress
TranscriptomicsExpression data from primary mouse hepatocytes treated with Diclofenac
Drug-induced liver injury (DILI) is an important clinical problem. Here we used a genomics approach to establish the critical drug-induced toxicity pathways that act in synergy with the pro-inflammatory cytokine tumor necrosis factor M-oM-^AM-! (TNFM-oM-^AM-!) to cause cell death of liver HepG2 cell...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-54256 | biostudies-arrayexpress
TranscriptomicsExpression data from human hepatocellular carcinoma cell line HepG2
Drug-induced liver injury (DILI) is an important clinical problem. Here we used a genomics approach to establish the critical drug-induced toxicity pathways that act in synergy with the pro-inflammatory cytokine tumor necrosis factor (TNF) to cause cell death of liver HepG2 cells. Transcriptomics of...
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-54254 | biostudies-arrayexpress
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