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MetabolomicsMicrobial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans
Plant fibers in byproduct streams produced by non-harsh food processing methods represent biorepositories of diverse, naturally occurring, and physiologically active biomolecules. To demonstrate one approach for their characterization, mass spectrometry of intestinal contents from gnotobiotic mice, ...
2022-07-28 | MTBLS2331 | MetaboLights
UnknownProfiling microbial strains in urban environments using metagenomic sequencing data.
Not available
S-EPMC5944035 | biostudies-literature
TranscriptomicsTranscription profiling by array of lymphoblastic cells, fat and skin from twins
Gene expression was quantified in LCL, skin and fat derived from a subset of Twins UK (N=156 LCL, N=160 skin, N=166 fat) using Illuminas whole genome expression array (HumanHT-12 version 3). Cis eQTL analysis was performed in each tissue, following by multiple analyses assessing the tissue-specifici...
ORGANISM(S): Homo sapiens 
2011-02-03 | E-MTAB-522 | biostudies-arrayexpress
TranscriptomicsDifferential neuronal targeting of a new and 2 known calcium channel M-NM-24 subunit splice variants correlates with their regulation of gene expression
The M-NM-2 subunits of voltage-gated calcium channels regulate surface expression and gating of CaV1 and CaV2 M-NM-11 subunits, and thus contribute to neuronal excitability, neurotransmitter release and calcium-induced gene regulation. In addition certain M-NM-2 subunits are targeted into the nucleu...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-50822 | biostudies-arrayexpress
TranscriptomicsIsocitrata Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/mir-200-Dependent Epithelial Mesenchymal Transition (EMT)
Mutations in the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a variety of tumor types, resulting in production of the proposed oncometabolite, 2-hydroxyglutarate (2-HG). How mutant IDH and 2-HG alter signaling pathways to promote cancer, though, remains unclear. Additionally, t...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-41802 | biostudies-arrayexpress
TranscriptomicsModel-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation
We used genome-scale modeling and multi-omics (transcriptomics, proteomics, and metabolomics) analysis to assess metabolic features that are critical for macrophage activation. We constructed a genome-scale metabolic network for the RAW 264.7 cell line to determine metabolic modulators of activation...
ORGANISM(S): Mus musculus 
2012-08-02 | E-GEOD-39785 | biostudies-arrayexpress
UnknownBody Mass Index and Metastatic Renal Cell Carcinoma: Clinical and Biological Correlations.
Not available
S-EPMC5065111 | biostudies-literature
OtherInflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.
Data from ProteomeXchange, PXD ID: PXD001500. Experiment: IFNAR_KO_Prog_78a, file: 120503_JH_IFNAR_KO_Prog_78a_10.mzml. Published as part of Cell Stem Cell. 2015 Aug 19. pii: S1934-5909(15)00306-9 . From the Abstract: {{i}} ... Here, we report that the phenotypic hematopoietic stem cell (HSC) compa...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310023393 | GPMDB
Resource Reanalysis 
GenomicsWhole Genome Profiling to Detect Schizophrenia Methylation Markers

Schizophrenia (SCZ) is a devastating psychiatric disorder. The aim of this study was to detect DNA methylation (5meC) profiles in whole blood associated with SCZ. The sample consisted of schizophrenia cases and controls selected from national population registers in Sweden. We employed MBD protei...

phs000608.v1.p1 | EGA
MetabolomicsModel-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation
Macrophages are central players in immune response, manifesting divergent phenotypes to control inflammation and innate immunity through release of cytokines and other signaling factors. Recently, the focus on metabolism has been reemphasized as critical signaling and regulatory pathways of human pa...
2012-09-05 | MTBLS23 | MetaboLights
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