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MetabolomicsPROMIS, global analysis of PROtein-Metabolite Interactions using Size separation in Arabidopsis thaliana
Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
TranscriptomicsPachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress
Background: Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this paper, we investigated the anticancer effects of PA on human chemotherapy resistant pancreatic cancer cells. Methods: Gemcitabine-resistant pancreatic cancer cells PANC-1 and MIA PaCa-2 were...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-64111 | biostudies-arrayexpress
UnknownIn vivo efficacy proof of concept of a large-size bioprinted dermo-epidermal substitute for permanent wound coverage.
Not available
S-EPMC10407941 | biostudies-literature
TranscriptomicsRNA at 92 M-BM-0C: the non-coding transcriptome of the hyperthermophilic archaeon Pyrococcus abyssi.
The non-coding transcriptome of the hyperthermophilic archaeon Pyrococcus abyssi is investigated using the RNA-seq technology. A dedicated computational pipeline analyzes RNA-seq reads and prior genome annotation to identify small RNAs, untranslated regions of mRNAs, and cis-encoded antisense transc...
ORGANISM(S): Pyrococcus abyssi 
2014-05-31 | E-GEOD-58131 | biostudies-arrayexpress
UnknownCOVID-19 as a potential trigger of complement-mediated atypical HUS.
Not available
S-EPMC8421074 | biostudies-literature
ProteomicsPhosphoProtein-Peptide Turnover Profiling, validation
We combined pulsed stable isotope labeling of amino acids (pSILAC) with enrichment of phosphorylated peptides in a method we term PhosphoProtein-Peptide Turnover Profiling (PhosphoPPToP). We applied the method to HeLa cells to find peptides whose clearance rates differ from the protein median. Using...
ORGANISM(S): Homo sapiens (Human) 
2022-12-02 | PXD032945 | Pride
Ap-ms Post-translational modification Protein maturation Gfp-fusion Pull-down Silac Protein turnover Phosphorylation Mass spectrometry Tmt16 
UnknownDrugs utilization profile in England and Wales in the past 15 years: a secular trend analysis.
Not available
S-EPMC9482186 | biostudies-literature
ProteomicsThiol-Based Direct Threat Sensing by the Stress-Activated Protein Kinase Hog1
The stress-activated protein kinase Hog1 is best known for its role in osmotic stress but is also activated by a variety of mechanistically distinct environmental stressors including heat shock, ER stress, and arsenic. In the osmotic stress response, the signal is sensed upstream and relayed to Hog1...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-12-04 | PXD015325 | Pride
Arsenic stress Yeast Tmt 
UnknownA deep Boltzmann machine-driven level set method for heart motion tracking using cine MRI images.
Not available
S-EPMC6501847 | biostudies-literature
ProteomicsMurine hippocampal phosphoproteome LC-MSMS
The hippocampus plays an important role in spatial memory and the conversion of short-term to long-term memory. Several studies have reported the presence of a peripheral oscillator in the hippocampus, and have highlighted the importance of circadian regulation in memory formation. In this study we ...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-11 | PXD005669 | Pride
Circadian Hippocampus Phosphoproteome Mouse 
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