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TranscriptomicsDynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (2)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63234 | biostudies-arrayexpress
GenomicsDynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (1)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63233 | biostudies-arrayexpress
TranscriptomicsDynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (3)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63235 | biostudies-arrayexpress
TranscriptomicsChIP-chip by array of human HeLa cells to characterize Methyl-CpG binding sites, RNA Polymerase 2 and methylated DNA regions
Chromatin immunoprecipitation coupled with microarray analysis (ChIP-chip) was carried out to characterize Methyl-CpG binding sites and RNA Polymerase 2 and methylateed DNA regions. Experiments were done in Hela cells.
ORGANISM(S): Homo sapiens 
2011-03-19 | E-MEXP-2634 | biostudies-arrayexpress
TranscriptomicsNucleotide composition-linked divergence of vertebrate core promoter architecture
Transcription initiation involves the recruitment of basal transcription factors to the core promoter. A variety of core promoter elements exists, however for most of these motifs the distribution across species is unknown. Here we report on the comparison of human and amphibian promoter sequences. ...
ORGANISM(S): Xenopus (Silurana) tropicalis 
2010-12-30 | E-GEOD-21482 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Hsd:ICR(CD-1) mouse intestines to study regional variations in ABC transporter expression along the mouse intestinal tract.
8 week-old male Hsd:ICR(CD-1) mice were fed ad libitum a standard chow (Harlan Teklad diet 2018S) and housed in groups of five. Animals were then divided into 3 pools (n=10) and sacrificed. The small intestine was extracted and divided into three sections, where the first 2-3 cm after the stomach co...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-849 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ataxin-null (Atxn-null) vs. wild type mice to investigate spinocerebellar ataxia type 1 (SCA1)
Ataxin 1 (Atxn1) is a protein of unknown function associated with cerebellar neurodegeneration in spinocerebellar ataxia type 1 (SCA1). SCA1 is caused by an expanded polyglutamine within Atxn1 by gain-of-function mechanisms. Lack of Atxn1 in mice triggers motor deficits in the absence of neurodegene...
ORGANISM(S): Mus musculus 
2006-12-01 | E-MEXP-886 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of acute myeloid leukemia patient samples for analysis of miR-29b expression
microRNA microarray data used for analysis of miR-29b expression in AML patient samples
ORGANISM(S): Homo sapiens 
2011-03-16 | E-TABM-944 | biostudies-arrayexpress
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