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ProteomicsAssessment of host hemoglobin accumulation in P. berghei heme pathway ferrochelatase knockout parasite food vacuole by iTRAQ
Two independent sets of fourplex iTRAQ labelling were carried out to assess the accumulation of host Hb in PbFCKO FVs. The results obtained have suggested that there is a ~3-4 -fold increase in Hb and chains in FCKO FVs as quantified by iTRAQ.
ORGANISM(S): Plasmodium Plasmodium berghei ANKA 
2022-05-10 | PXD031738 | Pride
Knockout (ko) Food vacuole (fv) Hemoglobin (hb) Wildtype (wt) Plasmodium berghei (pb) Ferrochelatase (fc) 
ProteomicsFood vacuole proteome of P. berghei heme pathway ferrochelatase knockout parasite by LC-MS/MS
LC-MS/MS of in-solution trypsin digested FV protein extracts was carried out for the FVs isolated from PbWT and PbFCKO parasites. The FV preparations had signature FV proteins such as plasmepsin IV, berghepain, aminopeptidases, subunits of vacuolar-type H+ATPase (V-type H ATPase), together with para...
ORGANISM(S): Plasmodium Plasmodium berghei ANKA 
2022-05-10 | PXD031736 | Pride
Knockout (ko) Food vacuole (fv) Wildtype (wt) Plasmodium berghei (pb) Ferrochelatase (fc) 
ProteomicsProteomic analysis of L-Methionine Sulfoximine (MSO)-treated Plasmodium falciparum by LC-MS/MS
LC-MS/MS of in-solution trypsin digested parasite protein extracts was carried out to examine the proteome of MSO-treated Pf parasites. Proteins were extracted from the untreated and MSO-treated parasite pellets of two independent experiments (Exp1: T7_R Vs T8; Exp2: T3_R Vs T4_R). For each experime...
ORGANISM(S): Plasmodium falciparum 58.1 
2023-05-27 | PXD032797 | Pride
Control Plasmodium falciparum (pf) Methionine sulfoximine (mso) Mso-treated 
UnknownApplication of Random Forest and data integration identifies three dysregulated genes and enrichment of Central Carbon Metabolism pathway in Oral Cancer.
Not available
S-EPMC7737291 | biostudies-literature
UnknownAssociation Between Plasma Diacetylspermine and Tumor Spermine Synthase With Outcome in Triple-Negative Breast Cancer.
Not available
S-EPMC7301069 | biostudies-literature
UnknownMalaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice.
Not available
S-EPMC9276668 | biostudies-literature
UnknownA naturalistic environment to study visual cognition in unrestrained monkeys.
Not available
S-EPMC8676323 | biostudies-literature
UnknownPlasmodium berghei HMGB1 controls the host immune responses and splenic clearance by regulating the expression of pir genes.
Not available
S-EPMC11541847 | biostudies-literature
ProteomicsGenome-scale CRISPR screens identify PTGES3 as a direct modulator of AR function in advanced prostate cancer
The androgen receptor (AR) is a critical driver of prostate cancer (PCa). To study regulators of AR protein levels and oncogenic activity, we created the first live cell quantitative endogenous AR fluorescent reporters. Leveraging this novel AR reporter, we performed genome-scale CRISPRi flow cytome...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD066297 | Pride
Ar Crispr screens Ptges3 Prostate cancer 
UnknownDistinct evolution of type I glutamine synthetase in Plasmodium and its species-specific requirement.
Not available
S-EPMC10349072 | biostudies-literature
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