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ProteomicsGenome-scale CRISPR screens identify PTGES3 as a direct modulator of AR function in advanced prostate cancer
The androgen receptor (AR) is a critical driver of prostate cancer (PCa). To study regulators of AR protein levels and oncogenic activity, we created the first live cell quantitative endogenous AR fluorescent reporters. Leveraging this novel AR reporter, we performed genome-scale CRISPRi flow cytome...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD066297 | Pride
Ar Crispr screens Ptges3 Prostate cancer 
UnknownPTGES3 proteolysis using the liposomal peptide-PROTAC approach.
Not available
S-EPMC11670498 | biostudies-literature
UnknownEffect of PTGES3 on the Prognosis and Immune Regulation in Lung Adenocarcinoma.
Not available
S-EPMC10322580 | biostudies-literature
UnknownComprehensive pan-cancer analysis of PTGES3 and its prognostic role in hepatocellular carcinoma.
Not available
S-EPMC10234500 | biostudies-literature
GenomicsGenome-wide flow sorting CRISPRi screen identify PTGES3 as a novel therapeutic target of AR
Genome-wide flow sorting CRISPRi screen identify PTGES3 as a novel therapeutic target of AR
PRJNA1240300 | ENA
GenomicsGenome-wide flow sorting CRISPRi screen identify PTGES3 as a novel therapeutic target of AR [ATAC-seq]
Genome-wide flow sorting CRISPRi screen identify PTGES3 as a novel therapeutic target of AR [ATAC-seq]
PRJNA746406 | ENA
GenomicsGenome-wide flow sorting CRISPRi screen identify PTGES3 as a novel therapeutic target of AR [mRNA-seq]
Genome-wide flow sorting CRISPRi screen identify PTGES3 as a novel therapeutic target of AR [mRNA-seq]
PRJNA746407 | ENA
GenomicsGenome-wide flow sorting CRISPRi screen identify PTGES3 as a novel therapeutic target of AR
Comprehensively understanding the gene regulatory network that modulates the biology of the Androgen Receptor (AR) oncogene is a central goal of prostate cancer research. To study regulators of AR, we knock-in a split neon green fluorescent protein onto the AR in prostate cancer cells creating an en...
ORGANISM(S): Homo sapiens 
2025-06-16 | GSE292612 | GEO
GenomicsGenome-wide flow sorting CRISPRi screen identify PTGES3 as a novel therapeutic target of AR [mRNA-seq_181-40]
Genome-wide flow sorting CRISPRi screen identify PTGES3 as a novel therapeutic target of AR [mRNA-seq_181-40]
PRJNA882921 | ENA
TranscriptomicsGenome-wide flow sorting CRISPRi screen identify PTGES3 as a novel therapeutic target of AR [mRNA-seq]
Comprehensively understanding the gene regulatory network that modulates the biology of the Androgen Receptor (AR) oncogene is a central goal of prostate cancer research. To study regulators of AR, we knock-in a split neon green fluorescent protein onto the AR in prostate cancer cells creating an en...
ORGANISM(S): Homo sapiens 
2025-06-16 | GSE180035 | GEO
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