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UnknownGenomic classifier identifies men with adverse pathology after radical prostatectomy who benefit from adjuvant radiation therapy.
Not available
S-EPMC4884273 | biostudies-literature
TranscriptomicsMechanism and transcriptional program of YB-1 in breast cancer cell lines.
YB-1 controls epithelial-mesenchymal transitions by restricting translation of growth-related mRNAs and enabling expression of EMT-inducing transcription factors. We used microarrays to characterize the direct transcriptional and indirect translational regulation of mRNAs by exogenous YB-1 in breast...
ORGANISM(S): Homo sapiens 
2008-10-30 | E-GEOD-13410 | biostudies-arrayexpress
TranscriptomicsTranscription Profiling of Formalin-Fixed Paraffin-Embedded Samples and fresh frozen samples by Affymetrix Microarrays as a qualitative assessment
Background: To date, few studies have systematically characterized microarray gene expression signal performance with degraded RNA from formalin-fixed paraffin-embedded (FFPE) specimens in comparison to intact RNA from unfixed fresh-frozen (FF) specimens. Methodology: RNA was extracted and isolated ...
ORGANISM(S): Homo sapiens 
2010-11-25 | E-GEOD-19249 | biostudies-arrayexpress
TranscriptomicsApplication of a clinical assay for staging and prognosis of prostate cancer diagnosed in needle core biopsy specimens
Molecular and genomic analysis of microscopic quantities of tumor from formalin-fixed and paraffin-embedded (FFPE) biopsies has many unique challenges. Here we evaluated the feasibility of obtaining transcriptome-wide RNA expression to measure prognostic classifiers from diagnostic prostate needle c...
ORGANISM(S): Homo sapiens 
2016-03-09 | E-GEOD-72220 | biostudies-arrayexpress
TranscriptomicsThe Hace1 E3 Ligase Modulates the Activity of Multiple Tumor Suppressive CRL E3 Ligases by binding to CAND1
The Hace1 E3 ligase is a tumor suppressor in stressed cells. Through unknown mechanisms, Hace1 indirectly targets the cyclin D1 proto-oncogene for proteasomal degradation during nutrient depletion. We now show that Hace1 targets HIF1alpha for VHL-dependent degradation during hypoxia. To better under...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-25452 | biostudies-arrayexpress
UnknownApplication of a Clinical Whole-Transcriptome Assay for Staging and Prognosis of Prostate Cancer Diagnosed in Needle Core Biopsy Specimens.
Not available
S-EPMC4851733 | biostudies-literature
TranscriptomicsDiscovery and validation of a novel expression signature for recurrence in high-risk bladder cancer post-cystectomy
Purpose: Selecting muscle-invasive bladder cancer patients for adjuvant therapy is currently based on clinical variables with limited power. We hypothesized that genomic-based signatures can outperform clinical models to identify patients at higher risk. Method:Transcriptome-wide expression profiles...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-57933 | biostudies-arrayexpress
TranscriptomicsValidation of a genomic classifier that predicts metastasis following radical prostatectomy in at risk patient population
Purpose: Patients with locally advanced prostate cancer after radical prostatectomy are candidates for secondary therapy. However, this higher risk population is heterogeneous. Many cases do not metastasize even when conservatively managed. Given the limited specificity of pathological features to p...
ORGANISM(S): Homo sapiens 
2014-11-13 | E-GEOD-62116 | biostudies-arrayexpress
GenomicsKUL-MEL Laboratory of Molecular Endocrinology, KU Leuven
Data Access Committee EGAC00001000260
EGAC00001000260 | EGA
Genomicsena-DATASET-KU-MEL-12-04-2016-11:46:48:538-274 - samples
Exome sequencing of high-risk prostate cancer
EGAD00001002009 | EGA
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