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TranscriptomicsA C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory
Microarray-based expression profiling of mixed stage populations taken from generation 1,13 and 26 spr-5 mutant animals as well as wild-type animals reveals a large class of spermatogenesis-expressed genes whose expression coordinately increased from generations 1 to 13 and then decreased from gener...
ORGANISM(S): Caenorhabditis elegans 
2010-06-19 | E-GEOD-14432 | biostudies-arrayexpress
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
UnknownDecreased memory B cells frequencies in COVID-19 Delta variant vaccine breakthrough infection
Not available
S-SCDT-EMM-2021-15227 | biostudies-other
TranscriptomicsTranscription profiling of mouse classically activated and type II activated macrophages to identify novel markers
The purpose of this study is to identify novel markers for the type II activated macrophage, which is generated by classical stimulation in the presence if IgG immune complexes. These cells gererally produce high levels of IL-10 and low levels of IL-12, in comparison to classically activated macroph...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4811 | biostudies-arrayexpress
TranscriptomicsA key role for a glutathione transferase in multiple herbicide resistance in grass weeds
The gene encoding a protein (AmGSTF1) associated with multiple herbicide resistance (MHR) in black-grass was transgenically expressed in Arabidopsis thaliana.The goal of this study was to determine if AmGSTF1 could elicit an MHR phenotype in the transgenic host. Affymetix microarrays were used to de...
ORGANISM(S): Arabidopsis thaliana 
2013-03-13 | E-GEOD-42065 | biostudies-arrayexpress
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: atrazine
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-03-23 | E-GEOD-21008 | biostudies-arrayexpress
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: fluoranthene
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-05-05 | E-GEOD-21011 | biostudies-arrayexpress
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: cadmium
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-05-05 | E-GEOD-21010 | biostudies-arrayexpress
UnknownPercutaneous Treatment of Proximal Migration of an Alterra Prestent.
Not available
S-EPMC11911862 | biostudies-literature
TranscriptomicsGene expression data from 131 human subjects in Detroit, Michigan
Background Complex diseases are often difficult to diagnose, treat and study due to the multi-factorial nature of the underlying etiology. Large data sets are now widely available that can be used to define novel, mechanistically distinct disease subtypes (endotypes) in a completely data-driven mann...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-35571 | biostudies-arrayexpress
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