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TranscriptomicsTranscriptomic analysis of human breast and prostate cancer cell lines on lysophosphatidic acid (LPA) stimulation
LPA is a natural bioactive lipid with growth factor-like functions due to activation of series of six G protein-coupled receptors (LPA1-6). In this study we determine the LPA induced early-gene expression profile in three unrelated human cancer cell lines (MDA-MB-231, MCF7, PC3) with an objective to...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-56265 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophages infected with Leishmania major or Leishmania donovani
Murine bone marrow derived macrophages were infected with Leishmania major or Leishmania donovania promastigotes, allowed to phagocytose latex beads or not treated. Gene expression profiles were compared to identify i) the effect of Leishmania infection; ii) the differences in effects between L. maj...
ORGANISM(S): Mus musculus 
2008-02-05 | E-MEXP-1254 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human Ewing sarcoma cells after knockdown of EGR2 or EWSR1-FLI1.
To get insight in the functional role of EGR2 for Ewing sarcoma, we performed a transcriptional profiling of Ewing sarcoma cells after knockdown of EGR2 and compared the resulting transcriptional signature with that of EWSR1-FLI1-silenced Ewing sarcoma cells. In accordance with the strong EGR2-induc...
ORGANISM(S): Homo sapiens 
2015-07-26 | E-GEOD-62090 | biostudies-arrayexpress
ProteomicsProteomic changes in mouse brain expressing WT and mutant (S3) alleles of the prion protein
Label-free quantification of proteomic changes in mouse expressing WT, mutant (S3) prion protein, and PrP-KO mouse. Three biological replicates were included per condition. In-gel digestion of the proteins extracted from brain generated 6 fractions per replicate.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-07-27 | MSV000092545 | MassIVE
ProteomicsN-terminal acetylation for identification of cleavage sites on immunoprecipitated PrP
In-gel N-terminal acetylation of immunoprecipitated prion protein for identification of cleavage sites. Mouse expressing either WT or mutant (S3) form of PrP were used in this study. Three replicates from single brains were included in this experiment.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-07-27 | MSV000092543 | MassIVE
ProteomicsSubtiligase N-terminomics for identification of cleavage sites in mice brain and immunoprecipitated PrP
Subtiligase-based N-terminomics (Abu N-terminal tagging) of whole mouse brain and immunoprecipitated prion protein. Mouse expressing either WT or mutant (S3) form of PrP were used in this study. Five replicates for single brain experiments and one replicate for combined brains approach are included....
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-07-27 | MSV000092542 | MassIVE
UnknownDoes Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma.
Not available
S-EPMC5070573 | biostudies-literature
ProteomicsMonkeypox and vaccinia virus infection of primary human astrocytes
Primary human astrocytes were infected with either monkeypox virus (MPXV clade IIb lineage), vaccinia virus (VACV: Acambis 2000), or controls (MC=monkeypox control, AC = Vaccinia control) at an MOI of 10 for 6 h. Samples (n=4) were analyzed by LC-MS/MS with label-free quantification where the data w...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-21 | MSV000092229 | MassIVE
UnknownBreast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism
Not available
S-SCDT-10_15252-EMBR_202357339 | biostudies-other
TranscriptomicsSSEA4 is a marker for chemotherapy resistance [mRNA]
By coupling PDX and cell surface marker screening technologies, we have identified distinct tumor cell sub-populations that are associated with tumor resistance to chemotherapy. In the majority of relapsed tumors, the percentage of the marker-positive cells shifted back to pretreatment levels. SSEA4...
ORGANISM(S): Homo sapiens 
2015-11-19 | E-GEOD-57703 | biostudies-arrayexpress
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