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TranscriptomicsBile-inducible membrane protein mediates the bile resistance phenotype of Bifidobacterium breve UCC2003
Bbr_0838 from Bifidobacterium breve UCC2003 encodes a 683 residue membrane protein, that contains a permease domain displaying similarity to transporters belonging to the major facilitator superfamily, as well as a CBS (cystathionine beta synthase) domain. The high level of similarity to bile-efflux...
ORGANISM(S): Bifidobacterium breve UCC2003 
2012-02-20 | E-GEOD-31224 | biostudies-arrayexpress
TranscriptomicsRole of SPI-1 Secreted Effectors, SipA, SopABDE2, in Acute Bovine Response to Salmonella enterica Serovar Typhimurium
Salmonella enterica Serovar Typhimurium (S. Typhimurium) causes enterocolitis in humans and calves characterized by diarrhea and polymorphonuclear cell (PMN) influx to the intestinal mucosa. The Salmonella Type III Secretion System encoded at Pathogenicity Island I (SPI-1) translocates the Salmonel...
ORGANISM(S): Bos taurus 
2012-01-10 | E-GEOD-13847 | biostudies-arrayexpress
TranscriptomicsCUT&Tag for RNAPII-Ser2p or RNAPII-Ser5p in DIS3-depleted cells
CUT&Tag was performed to identify the effect of DIS3 depletion on RNAPII in response to UV irradiation. DIS3-AID HCT116 cells were treated with either Auxin (for rapid depletion of DIS3) or DMSO (control) before irradiation with 8 J/m2 UVC. CUT&Tag was performed targeting RNAPII-Ser2p or RNAPII-Ser5...
ORGANISM(S): Homo sapiens 
2026-08-03 | E-MTAB-16280 | biostudies-arrayexpress
GenomicsStriatal genes regulated by super-enhancers and displaying low paused RNAPII are preferentially down-regulated in Huntington’s disease [ChIP-seq]
Huntington neurodegenerative disease (HD) is associated with extensive down-regulation of neuronal genes. We show preferential down-regulation of super-enhancer-regulated neuronal function genes in the striatum of HD mice. Striatal super-enhancers display extensive H3K27 acetylation within gene bodi...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-59570 | biostudies-arrayexpress
UnknownSpecific and off-target immune responses following COVID-19 vaccination with ChAdOx1-S and BNT162b2 vaccines-an exploratory sub-study of the BRACE trial.
Not available
S-EPMC11058726 | biostudies-literature
TranscriptomicsSignaling Pathways Deferentially Affect RNA Polymerase II Initiation, Pausing, and Elongation in Human Cells: TNF-alpha dependent signaling in AC16 cells
We used Global Run-on and Sequencing (GRO-seq) to measure the rate of transcription elongation by RNA polymerase II (Pol II) following gene activation. We observed that Pol II elongation rates can vary as much as 4-fold at different genomic loci and in response to two distinct cellular signaling pa...
ORGANISM(S): Homo sapiens 
2013-04-10 | E-GEOD-41323 | biostudies-arrayexpress
TranscriptomicsQuantitative analysis of proliferative and Ras-induced senescent human primary fibroblasts transcriptomes
The goals of this study is to analyse transcriptionnal changes in senescent cells and to compare them with ChIPseq data for several histones marks and proteins of the SUMO machinery mRNA profiling of proliferative versus Ras-induced senescent humain primary fibroblasts 5 days post-infection
ORGANISM(S): Homo sapiens 
2013-07-24 | E-GEOD-42212 | biostudies-arrayexpress
GenomicsEssential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
Malignant melanoma is an aggressive cancer known for its notorious resistance to most current therapies. The basic helix-loop-helix microphthalmia transcription factor (MITF) is the master regulator determining the identity and properties of the melanocyte lineage, and is regarded as a lineage-speci...
ORGANISM(S): Homo sapiens 
2014-12-13 | E-GEOD-64137 | biostudies-arrayexpress
TranscriptomicsDynamic Reorganization of the Cardiomyocyte Transcriptome in Response to TNFM-NM-1-induced Proinflammatory Signaling [GRO-Seq]
Inflammation is associated with many cardiovascular pathologies, but the underlying mechanisms remain unclear. To explore this in more detail, we characterized the transcriptome of an immortalized adult human ventricular cardiomyocyte cell line (AC16) in response to tumor necrosis factor (TNFa). U...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-51224 | biostudies-arrayexpress
GenomicsInterconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.
The conserved core domain of the TATA binding protein (TBP) interacts with multiple partners forming the complexes required for transcription by RNA Polymerases I, II and III. We use genetically modified mouse embryonic fibroblasts to show that many TBP core domain mutants complement loss of endogen...
ORGANISM(S): Mus musculus 
2012-03-01 | E-GEOD-27908 | biostudies-arrayexpress
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