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TranscriptomicsPseudomonas aeruginosa two-component regulator BfmR controls bacteriophage lysis and DNA release during biofilm development through PhdA
Biofilms are surface-adhered bacterial communities encased in an extracellular matrix composed of polysaccharides, proteins, and extracelluar (e)DNA, with eDNA being required for the formation and integrity of biofilms. Here we demonstrate that the spatial and temporal release of eDNA is regulated b...
ORGANISM(S): Pseudomonas aeruginosa 
2011-06-01 | E-GEOD-28953 | biostudies-arrayexpress
UnknownPromiscuous evolution of Group A Streptococcal M and M-like proteins.
Not available
S-EPMC9993116 | biostudies-literature
ProteomicsHypoxia promotes the generation of a versican-rich extracellular matrix by human coronary artery endothelial cells
• Exposure of endothelial cells (HCAECs) to hypoxia alters gene an protein expression • Genes and proteins related to endothelial dysfunction and activation are overexpressed • Hypoxia induces a versican-rich matrix with an altered glycosaminoglycan profile • This modified matrix perturbs cell adhes...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD052078 | Pride
Ecm Hypoxia Proteomics 
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
UnknownSystems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity.
Not available
S-EPMC7856305 | biostudies-literature
ProteomicsPeroxynitrite-mediated post-translational modification of human glutamine synthetase
The aim of the project was to understand the mechanisms that underlie the oxidative inactivation of human glutamine synthetase (HsGS). For that purpose, we expressed and purified recombinant HsGS, exposed it in phosphate buffer to peroxynitrite (ONOO-) and assessed the functional and structural cons...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037583 | Pride
Peroxynitrite Glutamine synthetase Oxidative stress Protein oxidation Nitrotyrosine 
UnknownOlaparib increases the therapeutic index of hemithoracic irradiation compared with hemithoracic irradiation alone in a mouse lung cancer model.
Not available
S-EPMC8144220 | biostudies-literature
UnknownPhosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
Not available
S-EPMC4769169 | biostudies-literature
UnknownGene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome.
Not available
S-EPMC3679143 | biostudies-literature
UnknownInfluence of cardiometabolic medications on abdominal aortic aneurysm growth in the UK Aneurysm Growth Study: metformin and angiotensin-converting enzyme inhibitors associated with slower aneurysm growth.
Not available
S-EPMC10763526 | biostudies-literature
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