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UnknownNatural Analogues in pH Variability and Predictability across the Coastal Pacific Estuaries: Extrapolation of the Increased Oyster Dissolution under Increased pH Amplitude and Low Predictability Related to Ocean Acidification.
Not available
S-EPMC9228044 | biostudies-literature
ProteomicsSFPQ-ABL1 and BCR-ABL1 utilise different signalling networks to drive B-cell acute lymphoblastic leukaemia
Philadelphia-like (Ph-like) acute lymphoblastic leukaemia (ALL) is a high-risk subtype of B-cell ALL characterised by a gene expression profile resembling Philadelphia Chromosome positive ALL (Ph+ ALL) in the absence of BCR-ABL1. Tyrosine kinase activating fusions, some involving ABL1, are recurrent...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD028925 | Pride
Abl1 Sfpq Bcr Leukaemia Aml 
TranscriptomicsEarly disruption of maternal-zygotic interaction and activation of defense-like responses in Arabidopsis interspecific incompatibility
Hybridization of diverged taxa often result in lethality or sterility. We previously described natural variation for postzygotic incompatibility in the cross of diploid Arabidopsis thaliana to Arabidopsis arenosa. Hybrid seed death in this system has a complex genetic basis, involving many non-addit...
ORGANISM(S): Arabidopsis thaliana 
2013-06-05 | E-GEOD-42957 | biostudies-arrayexpress
TranscriptomicsBRAF siRNA NHGRI_Liang_BRAF
BRAF, one of three RAF serine/threonine kinases (ARAF, BRAF and CRAF), plays a major role in the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signaling pathway, which mediates cellular responses to growth signals. Recently a high frequency (~60%-70%) of activating BRAF mutations (predomin...
ORGANISM(S): Homo sapiens 
2013-07-07 | E-GEOD-5481 | biostudies-arrayexpress
TranscriptomicsInfluenza peptide reactivity within a cohort of age-stratified individuals pre and post vaccination with the 2008/2009 trivalent influenza vaccine
The aim of the study was to test the hypothesis that peptide array reactivity will reveal patterns that can be associated with poor or effective neutralization response to seasonal influenza vaccine We diluted patient sera 1:80 and incubated dilutions on a streptavidin-coated glass surface that was ...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-43446 | biostudies-arrayexpress
TranscriptomicsCystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
Lung disease causes most of the morbidity and mortality in cystic fibrosis (CF). However, understanding its pathogenesis has been hindered by lack of an animal model with characteristic features of CF. To overcome this problem, we recently generated pigs with targeted CFTR genes. We now report that ...
ORGANISM(S): Sus scrofa 
2010-09-17 | E-GEOD-21071 | biostudies-arrayexpress
ModelsCD4 T cell signaling
Caveolin-1 (CAV1) is a vital scaffold protein heterogeneously expressed in both healthy and malignant tissue. We focus on the role of CAV1 when overexpressed in T-cell leukemia. Previously, we have shown that CAV1 is involved in cell-to-cell communication, cellular proliferation, and immune synapse ...
3521 | Cell Collective
TranscriptomicsComparative genomic hybridization of Clostridium sporogenes and Clostridium botulinum strains
Clostridium botulinum is a heterogeneous Gram-positive species that comprises four genetically and physiologically distinct groups of bacteria that share the ability to produce botulinum neurotoxin, the most poisonous toxin known to man, and the causative agent of botulism, a severe disease of human...
ORGANISM(S): Clostridium botulinum 
2007-05-23 | E-TABM-264 | biostudies-arrayexpress
GenomicsNational Cancer Institute Genome-Wide Association Study of Renal Cell Carcinoma

The National Cancer Institute (NCI) genome-wide association study (GWAS) of renal cell carcinoma (RCC) was conducted to investigate common genetic variants associated with RCC risk. The GWAS includes 1,453 RCC cases and 3,531 controls of European background from 4 studies (3 cohort, 1 case-con...

phs000351.v1.p1 | EGA
UnknownPrediction and Classification of Alzheimer's Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers.
Not available
S-EPMC6805777 | biostudies-literature
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