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TranscriptomicsMicroarray of zebrafish (Danio rerio) sfpq-/-;Tg(mnx1:GFP) against sfpq+/+;Tg(mnx1:GFP) and sfpq+/-;Tg(mnx1:GFP) siblings at 24 hpf
Phenotypic characterisation of our zebrafish sfpq homozygous mutants revealed a restricted set of specific defects, unexpected for a protein expressed ubiquitously and involved in such general mechanisms. The CNS was prominently affected, showing brain boundary and axonal defects associated with abs...
ORGANISM(S): Danio rerio 
2017-09-01 | E-MTAB-5559 | biostudies-arrayexpress
ProteomicsSFPQ-ABL1 and BCR-ABL1 utilise different signalling networks to drive B-cell acute lymphoblastic leukaemia
Philadelphia-like (Ph-like) acute lymphoblastic leukaemia (ALL) is a high-risk subtype of B-cell ALL characterised by a gene expression profile resembling Philadelphia Chromosome positive ALL (Ph+ ALL) in the absence of BCR-ABL1. Tyrosine kinase activating fusions, some involving ABL1, are recurrent...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD028925 | Pride
Abl1 Sfpq Bcr Leukaemia Aml 
ProteomicsAn alternative cytoplasmic SFPQ isoform with divergent phase separation potential is upregulated in ALS
Splicing factor proline- and glutamine-rich (SFPQ) is an RNA-binding protein that broadly regulates RNA metabolism. Although its nuclear roles are well-studied, evidence of SFPQ’s cytoplasmic functionality is emerging. Altered expression and nuclear-to-cytoplasmic mislocalisation of SFPQ is a hallma...
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD051918 | Pride
Cytoplasmic sfpq isoform Als 
ProteomicsSFPQ interacted proteins in HEK293T nucleus and cytoplasm
Splicing factor proline and glutamine rich (SFPQ), DNA- and RNA binding protein, is crucial in various nuclear processes, including paraspeckle formation, miRNA synthesis and specially in transcription regulation. In addition, SFPQ play a role in the innate immune response to viruses, including DNA ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-10 | PXD011865 | Pride
Sfpq  hek2893t  nucleus  cytoplasm 
TranscriptomicsRNA-seq of sfpq-/- zebrafish embryos and siblings at 24 hpf
RNA was extracted from whole zebrafish embryos at 24 hpf to examine changes in gene expression and splicing in sfpq null mutants
ORGANISM(S): Danio rerio 
2021-01-27 | E-MTAB-9113 | biostudies-arrayexpress
UnknownP-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis.
Not available
S-EPMC10012506 | biostudies-literature
GenomicsSFPQ promotes an oncogenic transcriptomic state in melanoma
SFPQ promotes an oncogenic transcriptomic state in melanoma
PRJNA719095 | ENA
TranscriptomicsEffects of SFPQ-TFE3 fusion in kidney tubuloids
The goal of this study was to analyse the effects of the SFPQ-TFE3 fusion by transforming kidney tubuloids with the construct. Samples without the construct (luciferase only) and overexpressing the partner only (TFE3) were also used as controls. Furthermore, transformed organoids were also transferr...
ORGANISM(S): Homo sapiens 
2025-02-28 | E-MTAB-13901 | biostudies-arrayexpress
GenomicsCharacterization of SFPQ role in ovarian cancer cell lines
Characterization of SFPQ role in ovarian cancer cell lines
PRJNA543992 | ENA
GenomicsSFPQ is a FTO binding protein that assists specific m6A demethylation
SFPQ is a FTO binding protein that assists specific m6A demethylation
PRJNA527761 | ENA
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