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TranscriptomicsVariation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects
Comprehensive sequencing of human cancers has identified recurrent mutations in genes encoding chromatin regulatory proteins. For clear cell renal cell carcinoma (ccRCC), three of the five commonly mutated genes encode the chromatin regulators PBRM1, SETD2, and BAP1. How these mutations alter the ch...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-MTAB-1936 | biostudies-arrayexpress
ProteomicsSpatial Proteomics of a Human Brain Tumour at 40 µm resolution
The spatial organisation of Cellular protein expression profiles within tissues determines cellular function and are key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for unbiased, quantitative technology capable of mapping prote...
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD044714 | Pride
Spatial proteomics Laser capture microdissection Roteomics 
ProteomicsSpatial Proteomics of a human brain tumour
The spatial organisation of Cellular protein expression profiles within tissues determines cellular function and are key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for unbiased, quantitative technology capable of mapping prote...
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD039159 | Pride
Spatial Laser capture microdissection Proteomics 
ProteomicsSpatial Proteomics of a Human Brain Tumour
The spatial organisation of Cellular protein expression profiles within tissues determines cellular function and are key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for unbiased, quantitative technology capable of mapping prote...
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD039398 | Pride
Spatial Laser capture microdissection Proteomics Maldi imaging 
ProteomicsA new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics.
Pregnancy induces significant physiological changes to support foetal growth, including critical adaptations in pancreatic islets for glucose homeostasis. This study elucidates these adaptations in human islets using immunohistochemistry, with a focus on α- and β-cell metrics, prolactin receptor (PR...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD055852 | Pride
Human Diabetes Pregnancy Pancreas 
ProteomicsDevelopment of a sensitive, scalable method for spatial, cell-type-resolved proteomics of the human brain
While nearly comprehensive proteome coverage can be achieved from bulk tissue or cultured cells, the data usually lacks spatial resolution. As a result, tissue based proteomics averages protein abundance across multiple cell types and/or localisations. With proteomics platforms lacking sensitivity a...
ORGANISM(S): Homo sapiens (Human) 
2019-03-04 | PXD012101 | Pride
Tissue proteomics Lc-ms/ms Brain Laser capture microdissection Spatially resolved proteomics 
TranscriptomicsFAIRE-seq in Rex1GFPd2 mouse embryonic stem cell line
Formaldehyde-assisted isolation of regulatory elements (FAIRE) in Rex1GFPd2 mouse ES cells (parental line; E14Tg2a)
ORGANISM(S): Mus musculus 
2014-06-24 | E-MTAB-2283 | biostudies-arrayexpress
ProteomicsA hybrid electrospun-extruded polydioxanone suture for tendon tissue regeneration
Many surgical tendon repairs fail despite advances in surgical materials and techniques. Tendon repair failure can be partially attributed to the tendon’s poor intrinsic healing capacity and the repurposing of sutures from use in other tissues. Electrospun materials show promise as a biological scaf...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD045312 | Pride
Human Tendon Tissue regeneration Plasma 
UnknownA higher rare CNV burden in the genetic background potentially contributes to intellectual disability phenotypes in 22q11.2 deletion syndrome.
Not available
S-EPMC6991138 | biostudies-literature
ProteomicsChaperonin CCT8 is essential for T cell development and function
T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. Here we demonstrate that the eukaryotic type II chaperonin complex CCT is indispensable for T cell development, function, stress-response, and met...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018834 | Pride
T cell Mouse T cell development Lc-ms/ms 
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