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ProteomicsAberrant neurodevelopment in human iPS cell-derived models of Alexander disease
Alexander disease (AxD) is a rare, severe neurodegenerative disorder caused by mutations in the glial fibrillary acidic protein (GFAP). While the exact disease mechanism remains unknown, existing studies suggest that the mutant GFAP influences many cellular processes, including cytoskeleton stabilit...
ORGANISM(S): Homo sapiens (Human) 
2024-09-09 | PXD048606 | Pride
Scrna-seq Alexander disease Gfap Ips cells Brain organoids 
ProteomicsComposition of Rosenthal fibers in Alexander disease patients and mouse models
Alexander disease (AxD) is a fatal neurodegenerative disorder characterized by the presence in astrocytes of protein aggregates called Rosenthal fibers (RFs). In this work, we used a new biochemical fractionation method to enrich for RFs followed by analysis of this fraction using quantitative iTRA...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2016-05-23 | PXD002448 | Pride
Alexander disease Rosenthal fibers Itraq 8-plex 
ProteomicsQuantitative Proteomic Analysis of an Alexander Disease Murine Model with Severe Reactive Gliosis
We performed label-free micro-data-independent acquisition (µDIA) to assay brain proteins from a severe model of Alexander disease (AxD, lethal at postnatal day ~35). Of the 5,005 proteins quantified, we observed upregulation of adipocytokine signaling, PPAR, insulin resistance, and glutathione pat...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-30 | PXD021884 | Pride
Reactive gliosis Alexander disease Parallel reaction monitoring Data-independent acquisition Brain proteome 
MetabolomicsAntibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria

Background

Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization and invasion. Antibiotic drugs t...

2020-09-28 | MTBLS1846 | MetaboLights
MetabolomicsMetabolomic and Metataxonomic Fingerprinting of Human Milk Suggests Compositional Stability over a Natural Term of Breastfeeding to 24 Months
Sparse data exist regarding the normal range of composition of maternal milk beyond the first postnatal weeks. This single timepoint, observational study in collaboration with the 'Parenting Science Gang' citizen science group evaluated the metabolite and bacterial composition of human milk from 62 ...
2022-02-11 | MTBLS1370 | MetaboLights
MetabolomicsMining for metabolic responses to long-term salt stress: a case study on the model legume Lotus japonicus (A)
Translational genomics, the use of model species to generate knowledge about biological processes and the functions of genes, offers great promise to biotechnologists. Few studies have sought robust responses of model plants to environmental stresses, such as salinity, by altering the stress dosage ...
2015-09-14 | MTBLS43 | MetaboLights
Unknown[Predictors of intensity of use of adult day care centers in people with cognitive impairment].
Not available
S-EPMC9587102 | biostudies-literature
TranscriptomicsDeep Sequencing of the Porcine Endometrial Transcriptome on Day 14 of Pregnancy
In pigs, conceptus attachment to the uterine surface epithelium starts around day 14 of pregnancy preceded by a pronounced vascularization at the implantation zones, initiating the epitheliochorial placentation. To characterize the complex transcriptome changes in the endometrium in the course of in...
ORGANISM(S): Sus scrofa 
2013-03-07 | E-GEOD-43667 | biostudies-arrayexpress
UnknownPredictors of falls and hospital admissions in people with cognitive impairment in day-care: role of multimorbidity, polypharmacy, and potentially inappropriate medication.
Not available
S-EPMC9387045 | biostudies-literature
ProteomicsAssessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition, including markers sST2, NT-proBNP and D-dimer
Head-down bed rest (HDBR) is one of the models of the physiological effects of weightlessness used, among other things, to assess the effect of hypokinesia on the physiological systems of the human body and, first of all, on the cardiovascular system. The aim of the work was to study the effect of 2...
ORGANISM(S): Homo sapiens (Human) 
2026-07-01 | PXD043604 | Pride
Head-down bed rest Mass spectrometry Nt-probnp D-dimer Sst2 
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